Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease
The kidney is an important organ for the maintenance of Ca<sup>2+</sup> homeostasis in the body. However, disruption of Ca<sup>2+</sup> homeostasis will cause a series of kidney diseases, such as acute kidney injury (AKI), chronic kidney disease (CKD), renal ischemia/reperfus...
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2021
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oai:doaj.org-article:6b5afc0a9b2243318c096ecdb89eee512021-11-25T17:12:51ZCalcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease10.3390/cells101132042073-4409https://doaj.org/article/6b5afc0a9b2243318c096ecdb89eee512021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3204https://doaj.org/toc/2073-4409The kidney is an important organ for the maintenance of Ca<sup>2+</sup> homeostasis in the body. However, disruption of Ca<sup>2+</sup> homeostasis will cause a series of kidney diseases, such as acute kidney injury (AKI), chronic kidney disease (CKD), renal ischemia/reperfusion (I/R) injury, autosomal dominant polycystic kidney disease (ADPKD), podocytopathy, and diabetic nephropathy. During the progression of kidney disease, Ca<sup>2+</sup> signaling plays key roles in various cell activities such as necrosis, apoptosis, eryptosis and autophagy. Importantly, there are complex Ca<sup>2+</sup> flux networks between the endoplasmic reticulum (ER), mitochondria and lysosomes which regulate intracellular Ca<sup>2+</sup> signaling in renal cells and contribute to kidney disease. In addition, Ca<sup>2+</sup> signaling also links the crosstalk between various cell deaths and autophagy under the stress of heavy metals or high glucose. In this regard, we present a review of Ca<sup>2+</sup> signaling in cell death and crosstalk with autophagy and its potential as a therapeutic target for the development of new and efficient drugs against kidney diseases.Bo NingChuanzhi GuoAnqi KongKongdong LiYimin XieHaifeng ShiJie GuMDPI AGarticleCa<sup>2+</sup> signalingcell deathautophagykidney diseasesBiology (General)QH301-705.5ENCells, Vol 10, Iss 3204, p 3204 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Ca<sup>2+</sup> signaling cell death autophagy kidney diseases Biology (General) QH301-705.5 |
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Ca<sup>2+</sup> signaling cell death autophagy kidney diseases Biology (General) QH301-705.5 Bo Ning Chuanzhi Guo Anqi Kong Kongdong Li Yimin Xie Haifeng Shi Jie Gu Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease |
| description |
The kidney is an important organ for the maintenance of Ca<sup>2+</sup> homeostasis in the body. However, disruption of Ca<sup>2+</sup> homeostasis will cause a series of kidney diseases, such as acute kidney injury (AKI), chronic kidney disease (CKD), renal ischemia/reperfusion (I/R) injury, autosomal dominant polycystic kidney disease (ADPKD), podocytopathy, and diabetic nephropathy. During the progression of kidney disease, Ca<sup>2+</sup> signaling plays key roles in various cell activities such as necrosis, apoptosis, eryptosis and autophagy. Importantly, there are complex Ca<sup>2+</sup> flux networks between the endoplasmic reticulum (ER), mitochondria and lysosomes which regulate intracellular Ca<sup>2+</sup> signaling in renal cells and contribute to kidney disease. In addition, Ca<sup>2+</sup> signaling also links the crosstalk between various cell deaths and autophagy under the stress of heavy metals or high glucose. In this regard, we present a review of Ca<sup>2+</sup> signaling in cell death and crosstalk with autophagy and its potential as a therapeutic target for the development of new and efficient drugs against kidney diseases. |
| format |
article |
| author |
Bo Ning Chuanzhi Guo Anqi Kong Kongdong Li Yimin Xie Haifeng Shi Jie Gu |
| author_facet |
Bo Ning Chuanzhi Guo Anqi Kong Kongdong Li Yimin Xie Haifeng Shi Jie Gu |
| author_sort |
Bo Ning |
| title |
Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease |
| title_short |
Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease |
| title_full |
Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease |
| title_fullStr |
Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease |
| title_full_unstemmed |
Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease |
| title_sort |
calcium signaling mediates cell death and crosstalk with autophagy in kidney disease |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/6b5afc0a9b2243318c096ecdb89eee51 |
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