Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

Mitochondrial oxidative phosphorylation produces ATP and is an important source for cellular energy equivalents. Here the authors perform a cell-based screen to identify genes that alleviate perturbed mitochondrial complex I function and identify malic enzyme (ME-1), which promotes survival by produ...

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Autores principales:	Eduardo Balsa, Elizabeth A. Perry, Christopher F. Bennett, Mark Jedrychowski, Steven P. Gygi, John G. Doench, Pere Puigserver
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b5c34283bc544b78083839339684cb7
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spelling	oai:doaj.org-article:6b5c34283bc544b78083839339684cb72021-12-02T15:02:55ZDefective NADPH production in mitochondrial disease complex I causes inflammation and cell death10.1038/s41467-020-16423-12041-1723https://doaj.org/article/6b5c34283bc544b78083839339684cb72020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16423-1https://doaj.org/toc/2041-1723Mitochondrial oxidative phosphorylation produces ATP and is an important source for cellular energy equivalents. Here the authors perform a cell-based screen to identify genes that alleviate perturbed mitochondrial complex I function and identify malic enzyme (ME-1), which promotes survival by production of NADPH and glutathione.Eduardo BalsaElizabeth A. PerryChristopher F. BennettMark JedrychowskiSteven P. GygiJohn G. DoenchPere PuigserverNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eduardo Balsa Elizabeth A. Perry Christopher F. Bennett Mark Jedrychowski Steven P. Gygi John G. Doench Pere Puigserver Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
description	Mitochondrial oxidative phosphorylation produces ATP and is an important source for cellular energy equivalents. Here the authors perform a cell-based screen to identify genes that alleviate perturbed mitochondrial complex I function and identify malic enzyme (ME-1), which promotes survival by production of NADPH and glutathione.
format	article
author	Eduardo Balsa Elizabeth A. Perry Christopher F. Bennett Mark Jedrychowski Steven P. Gygi John G. Doench Pere Puigserver
author_facet	Eduardo Balsa Elizabeth A. Perry Christopher F. Bennett Mark Jedrychowski Steven P. Gygi John G. Doench Pere Puigserver
author_sort	Eduardo Balsa
title	Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
title_short	Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
title_full	Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
title_fullStr	Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
title_full_unstemmed	Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
title_sort	defective nadph production in mitochondrial disease complex i causes inflammation and cell death
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6b5c34283bc544b78083839339684cb7
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Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

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