Endogenous cardiac stem cells for the treatment of heart failure

Tania Fuentes, Mary Kearns-Jonker Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA Abstract: Stem cell-based therapies hold promise for regenerating the myocardium after injury. Recent data obtained from phase I clinical trials using endogenous...

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Autores principales:	Fuentes T, Kearns-Jonker M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/6b5d438189ee4e1ead5f97082098c0ff
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spelling	oai:doaj.org-article:6b5d438189ee4e1ead5f97082098c0ff2021-12-02T01:30:10ZEndogenous cardiac stem cells for the treatment of heart failure1178-6957https://doaj.org/article/6b5d438189ee4e1ead5f97082098c0ff2013-03-01T00:00:00Zhttp://www.dovepress.com/endogenous-cardiac-stem-cells-for-the-treatment-of-heart-failure-a12566https://doaj.org/toc/1178-6957Tania Fuentes, Mary Kearns-Jonker Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA Abstract: Stem cell-based therapies hold promise for regenerating the myocardium after injury. Recent data obtained from phase I clinical trials using endogenous cardiovascular progenitors isolated directly from the heart suggest that cell-based treatment for heart patients using stem cells that reside in the heart provides significant functional benefit and an improvement in patient outcome. Methods to achieve improved engraftment and regeneration may extend this therapeutic benefit. Endogenous cardiovascular progenitors have been tested extensively in small animals to identify cells that improve cardiac function after myocardial infarction. However, the relative lack of large animal models impedes translation into clinical practice. This review will exclusively focus on the latest research pertaining to humans and large animals, including both endogenous and induced sources of cardiovascular progenitors. Keywords: Isl1, iPSC, large animal, c-kit, cardiosphereFuentes TKearns-Jonker MDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2013, Iss default, Pp 1-12 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Fuentes T Kearns-Jonker M Endogenous cardiac stem cells for the treatment of heart failure
description	Tania Fuentes, Mary Kearns-Jonker Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA Abstract: Stem cell-based therapies hold promise for regenerating the myocardium after injury. Recent data obtained from phase I clinical trials using endogenous cardiovascular progenitors isolated directly from the heart suggest that cell-based treatment for heart patients using stem cells that reside in the heart provides significant functional benefit and an improvement in patient outcome. Methods to achieve improved engraftment and regeneration may extend this therapeutic benefit. Endogenous cardiovascular progenitors have been tested extensively in small animals to identify cells that improve cardiac function after myocardial infarction. However, the relative lack of large animal models impedes translation into clinical practice. This review will exclusively focus on the latest research pertaining to humans and large animals, including both endogenous and induced sources of cardiovascular progenitors. Keywords: Isl1, iPSC, large animal, c-kit, cardiosphere
format	article
author	Fuentes T Kearns-Jonker M
author_facet	Fuentes T Kearns-Jonker M
author_sort	Fuentes T
title	Endogenous cardiac stem cells for the treatment of heart failure
title_short	Endogenous cardiac stem cells for the treatment of heart failure
title_full	Endogenous cardiac stem cells for the treatment of heart failure
title_fullStr	Endogenous cardiac stem cells for the treatment of heart failure
title_full_unstemmed	Endogenous cardiac stem cells for the treatment of heart failure
title_sort	endogenous cardiac stem cells for the treatment of heart failure
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/6b5d438189ee4e1ead5f97082098c0ff
work_keys_str_mv	AT fuentest endogenouscardiacstemcellsforthetreatmentofheartfailure AT kearnsjonkerm endogenouscardiacstemcellsforthetreatmentofheartfailure
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Endogenous cardiac stem cells for the treatment of heart failure

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