Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

The Ras/Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways are essential for cancer cell survival. Here, the authors describes a molecule a131 with dual-inhibitory properties, which targets PI5P4K and mitosis, and it is involved in Ras/Raf/MEK/ERK and PI3K/Akt/mTOR crosstalk, thereby causing reversibl...

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Autores principales:	Mayumi Kitagawa, Pei-Ju Liao, Kyung Hee Lee, Jasmine Wong, See Cheng Shang, Noriaki Minami, Oltea Sampetrean, Hideyuki Saya, Dai Lingyun, Nayana Prabhu, Go Ka Diam, Radoslaw Sobota, Andreas Larsson, Pär Nordlund, Frank McCormick, Sujoy Ghosh, David M. Epstein, Brian W. Dymock, Sang Hyun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b5dccbe0c124c53b9c0ce7603c0b8e2
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spelling	oai:doaj.org-article:6b5dccbe0c124c53b9c0ce7603c0b8e22021-12-02T14:40:45ZDual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality10.1038/s41467-017-02287-52041-1723https://doaj.org/article/6b5dccbe0c124c53b9c0ce7603c0b8e22017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02287-5https://doaj.org/toc/2041-1723The Ras/Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways are essential for cancer cell survival. Here, the authors describes a molecule a131 with dual-inhibitory properties, which targets PI5P4K and mitosis, and it is involved in Ras/Raf/MEK/ERK and PI3K/Akt/mTOR crosstalk, thereby causing reversible growth arrest in normal cells and cell death of tumor cells.Mayumi KitagawaPei-Ju LiaoKyung Hee LeeJasmine WongSee Cheng ShangNoriaki MinamiOltea SampetreanHideyuki SayaDai LingyunNayana PrabhuGo Ka DiamRadoslaw SobotaAndreas LarssonPär NordlundFrank McCormickSujoy GhoshDavid M. EpsteinBrian W. DymockSang Hyun LeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mayumi Kitagawa Pei-Ju Liao Kyung Hee Lee Jasmine Wong See Cheng Shang Noriaki Minami Oltea Sampetrean Hideyuki Saya Dai Lingyun Nayana Prabhu Go Ka Diam Radoslaw Sobota Andreas Larsson Pär Nordlund Frank McCormick Sujoy Ghosh David M. Epstein Brian W. Dymock Sang Hyun Lee Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
description	The Ras/Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways are essential for cancer cell survival. Here, the authors describes a molecule a131 with dual-inhibitory properties, which targets PI5P4K and mitosis, and it is involved in Ras/Raf/MEK/ERK and PI3K/Akt/mTOR crosstalk, thereby causing reversible growth arrest in normal cells and cell death of tumor cells.
format	article
author	Mayumi Kitagawa Pei-Ju Liao Kyung Hee Lee Jasmine Wong See Cheng Shang Noriaki Minami Oltea Sampetrean Hideyuki Saya Dai Lingyun Nayana Prabhu Go Ka Diam Radoslaw Sobota Andreas Larsson Pär Nordlund Frank McCormick Sujoy Ghosh David M. Epstein Brian W. Dymock Sang Hyun Lee
author_facet	Mayumi Kitagawa Pei-Ju Liao Kyung Hee Lee Jasmine Wong See Cheng Shang Noriaki Minami Oltea Sampetrean Hideyuki Saya Dai Lingyun Nayana Prabhu Go Ka Diam Radoslaw Sobota Andreas Larsson Pär Nordlund Frank McCormick Sujoy Ghosh David M. Epstein Brian W. Dymock Sang Hyun Lee
author_sort	Mayumi Kitagawa
title	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_short	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_full	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_fullStr	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_full_unstemmed	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
title_sort	dual blockade of the lipid kinase pip4ks and mitotic pathways leads to cancer-selective lethality
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6b5dccbe0c124c53b9c0ce7603c0b8e2
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Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

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