Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis

Abstract Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the g...

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Autores principales:	Fernanda Genre, Javier Rueda-Gotor, Sara Remuzgo-Martínez, Verónica Pulito-Cueto, Alfonso Corrales, Verónica Mijares, Leticia Lera-Gómez, Virginia Portilla, Rosa Expósito, Cristina Mata, Ricardo Blanco, Javier Llorca, Vanesa Hernández-Hernández, Esther Vicente, Cristina Fernández-Carballido, María Paz Martínez-Vidal, David Castro-Corredor, Joaquín Anino-Fernández, Carlos Rodríguez-Lozano, Oreste Gualillo, Juan Carlos Quevedo-Abeledo, Santos Castañeda, Iván Ferraz-Amaro, Raquel López-Mejías, Miguel Á. González-Gay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b5fb383f8884bf7ace58552d87fbe41
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spelling	oai:doaj.org-article:6b5fb383f8884bf7ace58552d87fbe412021-12-02T17:41:07ZOmentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis10.1038/s41598-020-66816-x2045-2322https://doaj.org/article/6b5fb383f8884bf7ace58552d87fbe412020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66816-xhttps://doaj.org/toc/2045-2322Abstract Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the genetic and functional implication of omentin in CV risk and subclinical atherosclerosis in a cohort of 385 axSpA patients. Subclinical atherosclerosis was evaluated by carotid ultrasound. Omentin rs12409609, in linkage disequilibrium with a polymorphism associated with CV risk, was genotyped in 385 patients and 84 controls. Serum omentin levels were also determined. omentin mRNA expression was assessed in a subgroup of individuals. Serum and mRNA omentin levels were lower in axSpA compared to controls. Low serum omentin levels were related to male sex, obesity, inflammatory bowel disease (IBD) and high atherogenic index. rs12409609 minor allele was associated with low omentin mRNA expression in axSpA. No association was observed with subclinical atherosclerosis at the genetic or functional level. In conclusion, in our study low omentin serum levels were associated with CV risk factors in axSpA. Furthermore, rs12409609 minor allele may be downregulating the expression of omentin. These data support a role of omentin as a CV risk biomarker in axSpA.Fernanda GenreJavier Rueda-GotorSara Remuzgo-MartínezVerónica Pulito-CuetoAlfonso CorralesVerónica MijaresLeticia Lera-GómezVirginia PortillaRosa ExpósitoCristina MataRicardo BlancoJavier LlorcaVanesa Hernández-HernándezEsther VicenteCristina Fernández-CarballidoMaría Paz Martínez-VidalDavid Castro-CorredorJoaquín Anino-FernándezCarlos Rodríguez-LozanoOreste GualilloJuan Carlos Quevedo-AbeledoSantos CastañedaIván Ferraz-AmaroRaquel López-MejíasMiguel Á. González-GayNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fernanda Genre Javier Rueda-Gotor Sara Remuzgo-Martínez Verónica Pulito-Cueto Alfonso Corrales Verónica Mijares Leticia Lera-Gómez Virginia Portilla Rosa Expósito Cristina Mata Ricardo Blanco Javier Llorca Vanesa Hernández-Hernández Esther Vicente Cristina Fernández-Carballido María Paz Martínez-Vidal David Castro-Corredor Joaquín Anino-Fernández Carlos Rodríguez-Lozano Oreste Gualillo Juan Carlos Quevedo-Abeledo Santos Castañeda Iván Ferraz-Amaro Raquel López-Mejías Miguel Á. González-Gay Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
description	Abstract Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the genetic and functional implication of omentin in CV risk and subclinical atherosclerosis in a cohort of 385 axSpA patients. Subclinical atherosclerosis was evaluated by carotid ultrasound. Omentin rs12409609, in linkage disequilibrium with a polymorphism associated with CV risk, was genotyped in 385 patients and 84 controls. Serum omentin levels were also determined. omentin mRNA expression was assessed in a subgroup of individuals. Serum and mRNA omentin levels were lower in axSpA compared to controls. Low serum omentin levels were related to male sex, obesity, inflammatory bowel disease (IBD) and high atherogenic index. rs12409609 minor allele was associated with low omentin mRNA expression in axSpA. No association was observed with subclinical atherosclerosis at the genetic or functional level. In conclusion, in our study low omentin serum levels were associated with CV risk factors in axSpA. Furthermore, rs12409609 minor allele may be downregulating the expression of omentin. These data support a role of omentin as a CV risk biomarker in axSpA.
format	article
author	Fernanda Genre Javier Rueda-Gotor Sara Remuzgo-Martínez Verónica Pulito-Cueto Alfonso Corrales Verónica Mijares Leticia Lera-Gómez Virginia Portilla Rosa Expósito Cristina Mata Ricardo Blanco Javier Llorca Vanesa Hernández-Hernández Esther Vicente Cristina Fernández-Carballido María Paz Martínez-Vidal David Castro-Corredor Joaquín Anino-Fernández Carlos Rodríguez-Lozano Oreste Gualillo Juan Carlos Quevedo-Abeledo Santos Castañeda Iván Ferraz-Amaro Raquel López-Mejías Miguel Á. González-Gay
author_facet	Fernanda Genre Javier Rueda-Gotor Sara Remuzgo-Martínez Verónica Pulito-Cueto Alfonso Corrales Verónica Mijares Leticia Lera-Gómez Virginia Portilla Rosa Expósito Cristina Mata Ricardo Blanco Javier Llorca Vanesa Hernández-Hernández Esther Vicente Cristina Fernández-Carballido María Paz Martínez-Vidal David Castro-Corredor Joaquín Anino-Fernández Carlos Rodríguez-Lozano Oreste Gualillo Juan Carlos Quevedo-Abeledo Santos Castañeda Iván Ferraz-Amaro Raquel López-Mejías Miguel Á. González-Gay
author_sort	Fernanda Genre
title	Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
title_short	Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
title_full	Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
title_fullStr	Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
title_full_unstemmed	Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
title_sort	omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6b5fb383f8884bf7ace58552d87fbe41
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Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis

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