Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis

Abstract Introduction Circular RNAs (circRNAs) play critical roles in tumorigenesis, but their clinical efficacy in esophageal squamous cell carcinoma (ESCC) still retains controversial. This meta‐analysis aims at evaluating the associations between circRNA expressions and clinicopathologic features...

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Autores principales:	Chengcheng Guo, Jianqiang Mi, Haike Li, Panke Su, He Nie
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	circular RNA diagnoses esophageal squamous cell carcinoma meta‐analysis prognoses Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6b622c0978174a48b67b399764ca763a
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spelling	oai:doaj.org-article:6b622c0978174a48b67b399764ca763a2021-11-22T09:08:47ZDysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis2045-763410.1002/cam4.3703https://doaj.org/article/6b622c0978174a48b67b399764ca763a2021-11-01T00:00:00Zhttps://doi.org/10.1002/cam4.3703https://doaj.org/toc/2045-7634Abstract Introduction Circular RNAs (circRNAs) play critical roles in tumorigenesis, but their clinical efficacy in esophageal squamous cell carcinoma (ESCC) still retains controversial. This meta‐analysis aims at evaluating the associations between circRNA expressions and clinicopathologic features as well as the diagnostic and prognostic values of circRNAs in ESCC. Materials & Methods PubMed, EMBASE, and other online databases were systematically searched to collect studies on circRNAs and clinicopathological features, diagnostic, and/or prognostic assessments of ESCC. The quality of included studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS‐2) and Newcastle‐Ottawa Scale (NOS) scales. The included studies were quantitatively weighted and merged, and diagnostic indicators, hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were calculated. P values were merged by Fisher᾽s method. Sources of heterogeneity were traced using subgroup, sensitivity, and meta‐regression analyses. Results As a result, 12 studies were included, representing 769 ESCC patients. The meta‐analysis showed that abnormal expressions of circRNAs were associated to TNM stage as well as lymph node and distant metastases in ESCC cases. CircRNA was used to distinguish ESCC patients from healthy controls, and the merged sensitivity, specificity, and the area under the curve (AUC) of ESCC were 0.78 (95% CI: 0.74–0.81), 0.79 (95% CI: 0.75–0.83), and 0.86, respectively. The survival analysis showed that upregulated oncogenic circRNA levels in ESCC tissues was associated with the shorter overall survival (OS) of the patients (univariate analysis: HR = 2.25, 95% CI: 1.71–2.95, p = 0.000, I2 = 0.0%; multivariate analysis: HR = 2.50, 95% CI: 1.61–3.89, p = 0.000, I2 = 0.0%), while the OS of ESCC patients presenting overexpressions of tumor‐suppressive circRNAs was significantly ameliorated (HR = 0.29, 95% CI: 0.20–0.42, p = 0.000, I2 = 0.0%). The subgroup analyses based on circRNA biofunctions, sample size, and reference gene also revealed robust results. Conclusion CircRNAs can be used as promising molecular biomarkers for the early diagnosis and prognosis monitoring of ESCC.Chengcheng GuoJianqiang MiHaike LiPanke SuHe NieWileyarticlecircular RNAdiagnosesesophageal squamous cell carcinomameta‐analysisprognosesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 22, Pp 7895-7908 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circular RNA diagnoses esophageal squamous cell carcinoma meta‐analysis prognoses Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	circular RNA diagnoses esophageal squamous cell carcinoma meta‐analysis prognoses Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chengcheng Guo Jianqiang Mi Haike Li Panke Su He Nie Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis
description	Abstract Introduction Circular RNAs (circRNAs) play critical roles in tumorigenesis, but their clinical efficacy in esophageal squamous cell carcinoma (ESCC) still retains controversial. This meta‐analysis aims at evaluating the associations between circRNA expressions and clinicopathologic features as well as the diagnostic and prognostic values of circRNAs in ESCC. Materials & Methods PubMed, EMBASE, and other online databases were systematically searched to collect studies on circRNAs and clinicopathological features, diagnostic, and/or prognostic assessments of ESCC. The quality of included studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS‐2) and Newcastle‐Ottawa Scale (NOS) scales. The included studies were quantitatively weighted and merged, and diagnostic indicators, hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were calculated. P values were merged by Fisher᾽s method. Sources of heterogeneity were traced using subgroup, sensitivity, and meta‐regression analyses. Results As a result, 12 studies were included, representing 769 ESCC patients. The meta‐analysis showed that abnormal expressions of circRNAs were associated to TNM stage as well as lymph node and distant metastases in ESCC cases. CircRNA was used to distinguish ESCC patients from healthy controls, and the merged sensitivity, specificity, and the area under the curve (AUC) of ESCC were 0.78 (95% CI: 0.74–0.81), 0.79 (95% CI: 0.75–0.83), and 0.86, respectively. The survival analysis showed that upregulated oncogenic circRNA levels in ESCC tissues was associated with the shorter overall survival (OS) of the patients (univariate analysis: HR = 2.25, 95% CI: 1.71–2.95, p = 0.000, I2 = 0.0%; multivariate analysis: HR = 2.50, 95% CI: 1.61–3.89, p = 0.000, I2 = 0.0%), while the OS of ESCC patients presenting overexpressions of tumor‐suppressive circRNAs was significantly ameliorated (HR = 0.29, 95% CI: 0.20–0.42, p = 0.000, I2 = 0.0%). The subgroup analyses based on circRNA biofunctions, sample size, and reference gene also revealed robust results. Conclusion CircRNAs can be used as promising molecular biomarkers for the early diagnosis and prognosis monitoring of ESCC.
format	article
author	Chengcheng Guo Jianqiang Mi Haike Li Panke Su He Nie
author_facet	Chengcheng Guo Jianqiang Mi Haike Li Panke Su He Nie
author_sort	Chengcheng Guo
title	Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis
title_short	Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis
title_full	Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis
title_fullStr	Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis
title_full_unstemmed	Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis
title_sort	dysregulated circular rnas as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/6b622c0978174a48b67b399764ca763a
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_version_	1718417799788888064

Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta‐analysis

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