CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum

CHARGE syndrome that affects cerebellar development can be caused by haploinsufficiency of the chromatin remodeling enzyme CHD7; however the precise role of CHD7 remains unknown. Here the authors show CHD7 promotes chromatin accessibility and enhancer activity in granule cell precursors and regulate...

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Autores principales:	Naveen C. Reddy, Shahriyar P. Majidi, Lingchun Kong, Mati Nemera, Cole J. Ferguson, Michael Moore, Tassia M. Goncalves, Hai-Kun Liu, James A. J. Fitzpatrick, Guoyan Zhao, Tomoko Yamada, Azad Bonni, Harrison W. Gabel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b65df7f5b89436183b44caa5fad1079
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spelling	oai:doaj.org-article:6b65df7f5b89436183b44caa5fad10792021-12-02T18:51:22ZCHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum10.1038/s41467-021-25846-32041-1723https://doaj.org/article/6b65df7f5b89436183b44caa5fad10792021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25846-3https://doaj.org/toc/2041-1723CHARGE syndrome that affects cerebellar development can be caused by haploinsufficiency of the chromatin remodeling enzyme CHD7; however the precise role of CHD7 remains unknown. Here the authors show CHD7 promotes chromatin accessibility and enhancer activity in granule cell precursors and regulates morphogenesis of the cerebellar cortex, where loss of CHD7 triggers cerebellar polymicrogyria.Naveen C. ReddyShahriyar P. MajidiLingchun KongMati NemeraCole J. FergusonMichael MooreTassia M. GoncalvesHai-Kun LiuJames A. J. FitzpatrickGuoyan ZhaoTomoko YamadaAzad BonniHarrison W. GabelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naveen C. Reddy Shahriyar P. Majidi Lingchun Kong Mati Nemera Cole J. Ferguson Michael Moore Tassia M. Goncalves Hai-Kun Liu James A. J. Fitzpatrick Guoyan Zhao Tomoko Yamada Azad Bonni Harrison W. Gabel CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum
description	CHARGE syndrome that affects cerebellar development can be caused by haploinsufficiency of the chromatin remodeling enzyme CHD7; however the precise role of CHD7 remains unknown. Here the authors show CHD7 promotes chromatin accessibility and enhancer activity in granule cell precursors and regulates morphogenesis of the cerebellar cortex, where loss of CHD7 triggers cerebellar polymicrogyria.
format	article
author	Naveen C. Reddy Shahriyar P. Majidi Lingchun Kong Mati Nemera Cole J. Ferguson Michael Moore Tassia M. Goncalves Hai-Kun Liu James A. J. Fitzpatrick Guoyan Zhao Tomoko Yamada Azad Bonni Harrison W. Gabel
author_facet	Naveen C. Reddy Shahriyar P. Majidi Lingchun Kong Mati Nemera Cole J. Ferguson Michael Moore Tassia M. Goncalves Hai-Kun Liu James A. J. Fitzpatrick Guoyan Zhao Tomoko Yamada Azad Bonni Harrison W. Gabel
author_sort	Naveen C. Reddy
title	CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum
title_short	CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum
title_full	CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum
title_fullStr	CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum
title_full_unstemmed	CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum
title_sort	charge syndrome protein chd7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b65df7f5b89436183b44caa5fad1079
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CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum

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