Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders

Autism spectrum disorder is approximately 4.5 times more likely to occur in boys than girls. Here, Werling, Geschwind and Parikshak characterized sexually dimorphic gene expression in the non-diseased, post-mortem, adult and prenatal human brain, and show genes expressed at higher levels in males ar...

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Autores principales: Donna M. Werling, Neelroop N. Parikshak, Daniel H. Geschwind
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6b6727ff2fe1413bb656425f561cb443
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spelling oai:doaj.org-article:6b6727ff2fe1413bb656425f561cb4432021-12-02T17:32:53ZGene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders10.1038/ncomms107172041-1723https://doaj.org/article/6b6727ff2fe1413bb656425f561cb4432016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10717https://doaj.org/toc/2041-1723Autism spectrum disorder is approximately 4.5 times more likely to occur in boys than girls. Here, Werling, Geschwind and Parikshak characterized sexually dimorphic gene expression in the non-diseased, post-mortem, adult and prenatal human brain, and show genes expressed at higher levels in males are significantly enriched for genes upregulated in autistic brain.Donna M. WerlingNeelroop N. ParikshakDaniel H. GeschwindNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Donna M. Werling
Neelroop N. Parikshak
Daniel H. Geschwind
Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
description Autism spectrum disorder is approximately 4.5 times more likely to occur in boys than girls. Here, Werling, Geschwind and Parikshak characterized sexually dimorphic gene expression in the non-diseased, post-mortem, adult and prenatal human brain, and show genes expressed at higher levels in males are significantly enriched for genes upregulated in autistic brain.
format article
author Donna M. Werling
Neelroop N. Parikshak
Daniel H. Geschwind
author_facet Donna M. Werling
Neelroop N. Parikshak
Daniel H. Geschwind
author_sort Donna M. Werling
title Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
title_short Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
title_full Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
title_fullStr Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
title_full_unstemmed Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
title_sort gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/6b6727ff2fe1413bb656425f561cb443
work_keys_str_mv AT donnamwerling geneexpressioninhumanbrainimplicatessexuallydimorphicpathwaysinautismspectrumdisorders
AT neelroopnparikshak geneexpressioninhumanbrainimplicatessexuallydimorphicpathwaysinautismspectrumdisorders
AT danielhgeschwind geneexpressioninhumanbrainimplicatessexuallydimorphicpathwaysinautismspectrumdisorders
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