Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
Autism spectrum disorder is approximately 4.5 times more likely to occur in boys than girls. Here, Werling, Geschwind and Parikshak characterized sexually dimorphic gene expression in the non-diseased, post-mortem, adult and prenatal human brain, and show genes expressed at higher levels in males ar...
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Nature Portfolio
2016
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oai:doaj.org-article:6b6727ff2fe1413bb656425f561cb4432021-12-02T17:32:53ZGene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders10.1038/ncomms107172041-1723https://doaj.org/article/6b6727ff2fe1413bb656425f561cb4432016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10717https://doaj.org/toc/2041-1723Autism spectrum disorder is approximately 4.5 times more likely to occur in boys than girls. Here, Werling, Geschwind and Parikshak characterized sexually dimorphic gene expression in the non-diseased, post-mortem, adult and prenatal human brain, and show genes expressed at higher levels in males are significantly enriched for genes upregulated in autistic brain.Donna M. WerlingNeelroop N. ParikshakDaniel H. GeschwindNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
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Science Q Donna M. Werling Neelroop N. Parikshak Daniel H. Geschwind Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders |
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Autism spectrum disorder is approximately 4.5 times more likely to occur in boys than girls. Here, Werling, Geschwind and Parikshak characterized sexually dimorphic gene expression in the non-diseased, post-mortem, adult and prenatal human brain, and show genes expressed at higher levels in males are significantly enriched for genes upregulated in autistic brain. |
format |
article |
author |
Donna M. Werling Neelroop N. Parikshak Daniel H. Geschwind |
author_facet |
Donna M. Werling Neelroop N. Parikshak Daniel H. Geschwind |
author_sort |
Donna M. Werling |
title |
Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders |
title_short |
Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders |
title_full |
Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders |
title_fullStr |
Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders |
title_full_unstemmed |
Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders |
title_sort |
gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/6b6727ff2fe1413bb656425f561cb443 |
work_keys_str_mv |
AT donnamwerling geneexpressioninhumanbrainimplicatessexuallydimorphicpathwaysinautismspectrumdisorders AT neelroopnparikshak geneexpressioninhumanbrainimplicatessexuallydimorphicpathwaysinautismspectrumdisorders AT danielhgeschwind geneexpressioninhumanbrainimplicatessexuallydimorphicpathwaysinautismspectrumdisorders |
_version_ |
1718380125311991808 |