Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1

Patel et al. report crystal structures of the kinase domain of Doublecortin-like kinase 1 (DCLK1) in complex with a potent inhibitor and its precursors. Their structural study reveals insights into the mode of action of the inhibitor DCLK1-IN-1 and sets the basis for the design of isoform-specific i...

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Auteurs principaux:	Onisha Patel, Michael J. Roy, Ashleigh Kropp, Joshua M. Hardy, Weiwen Dai, Isabelle S. Lucet
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/6b6a664c847645569a2bc4e72fd9c9cb
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spelling	oai:doaj.org-article:6b6a664c847645569a2bc4e72fd9c9cb2021-12-02T17:26:48ZStructural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-110.1038/s42003-021-02631-y2399-3642https://doaj.org/article/6b6a664c847645569a2bc4e72fd9c9cb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02631-yhttps://doaj.org/toc/2399-3642Patel et al. report crystal structures of the kinase domain of Doublecortin-like kinase 1 (DCLK1) in complex with a potent inhibitor and its precursors. Their structural study reveals insights into the mode of action of the inhibitor DCLK1-IN-1 and sets the basis for the design of isoform-specific inhibitors of DCLK1, which plays a role in tumour growth and development.Onisha PatelMichael J. RoyAshleigh KroppJoshua M. HardyWeiwen DaiIsabelle S. LucetNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Onisha Patel Michael J. Roy Ashleigh Kropp Joshua M. Hardy Weiwen Dai Isabelle S. Lucet Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
description	Patel et al. report crystal structures of the kinase domain of Doublecortin-like kinase 1 (DCLK1) in complex with a potent inhibitor and its precursors. Their structural study reveals insights into the mode of action of the inhibitor DCLK1-IN-1 and sets the basis for the design of isoform-specific inhibitors of DCLK1, which plays a role in tumour growth and development.
format	article
author	Onisha Patel Michael J. Roy Ashleigh Kropp Joshua M. Hardy Weiwen Dai Isabelle S. Lucet
author_facet	Onisha Patel Michael J. Roy Ashleigh Kropp Joshua M. Hardy Weiwen Dai Isabelle S. Lucet
author_sort	Onisha Patel
title	Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
title_short	Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
title_full	Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
title_fullStr	Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
title_full_unstemmed	Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
title_sort	structural basis for small molecule targeting of doublecortin like kinase 1 with dclk1-in-1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b6a664c847645569a2bc4e72fd9c9cb
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Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1

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