Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway

Replicative and non-replicative H3 variants have different cell cycle regulation and incorporation modes. Here, the authors identify H3.3 S31 deposition as key at Xenopus gastrulation, independently of the pathways; and characterize H3.3 S31 phosphorylation importance for the underlying mechanisms.

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Auteurs principaux: David Sitbon, Ekaterina Boyarchuk, Florent Dingli, Damarys Loew, Geneviève Almouzni
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/6b6fa19d666d4ac597e0b95866bcdfb9
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Résumé:Replicative and non-replicative H3 variants have different cell cycle regulation and incorporation modes. Here, the authors identify H3.3 S31 deposition as key at Xenopus gastrulation, independently of the pathways; and characterize H3.3 S31 phosphorylation importance for the underlying mechanisms.