The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer

Abstract Formyl peptide receptors (FPRs) are G protein-coupled chemoattractant receptors expressed mainly in phagocytic leukocytes. High expression of FPRs has also been detected in several cancers but the functions of FPR1 in tumor invasion and metastasis is poorly understood. In this study, we inv...

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Autores principales:	Shu-Qin Li, Ning Su, Ping Gong, Hai-Bo Zhang, Jin Liu, Ding Wang, Yan-Ping Sun, Yan Zhang, Feng Qian, Bo Zhao, Yang Yu, Richard D. Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b7858b479434370b805fc8952c9b037
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spelling	oai:doaj.org-article:6b7858b479434370b805fc8952c9b0372021-12-02T15:06:19ZThe Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer10.1038/s41598-017-06368-92045-2322https://doaj.org/article/6b7858b479434370b805fc8952c9b0372017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06368-9https://doaj.org/toc/2045-2322Abstract Formyl peptide receptors (FPRs) are G protein-coupled chemoattractant receptors expressed mainly in phagocytic leukocytes. High expression of FPRs has also been detected in several cancers but the functions of FPR1 in tumor invasion and metastasis is poorly understood. In this study, we investigated the expression of FPRs in primary human colorectal cancer (CRC) and analyzed the association of FPRs expression with clinicopathological parameters. The levels of FPRs mRNA, especially those of FPR1, were significantly higher in colorectal tumors than in distant normal tissues and adjacent non-tumor tissues. FPR1 mRNA expression was also associated with tumor serosal infiltration. FPR1 protein expression was both in the colorectal epitheliums and tumor infiltrating neutrophils/macrophages. Furthermore, the functions of FPR1 in tumor invasion and tissue repair were investigated using the CRC cell lines SW480 and HT29. Higher cell surface expression of FPR1 is associated with significantly increased migration in SW480 cells compared with HT29 cells that have less FPR1 membrane expression. Finally, genetic deletion of fpr1 increased the survival rate of the resulting knockout mice compared with wild type littermates in a mouse model of colitis-associated colorectal cancer. Our data demonstrate that FPR1 may play an important role in tumor cell invasion in CRC patients.Shu-Qin LiNing SuPing GongHai-Bo ZhangJin LiuDing WangYan-Ping SunYan ZhangFeng QianBo ZhaoYang YuRichard D. YeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shu-Qin Li Ning Su Ping Gong Hai-Bo Zhang Jin Liu Ding Wang Yan-Ping Sun Yan Zhang Feng Qian Bo Zhao Yang Yu Richard D. Ye The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer
description	Abstract Formyl peptide receptors (FPRs) are G protein-coupled chemoattractant receptors expressed mainly in phagocytic leukocytes. High expression of FPRs has also been detected in several cancers but the functions of FPR1 in tumor invasion and metastasis is poorly understood. In this study, we investigated the expression of FPRs in primary human colorectal cancer (CRC) and analyzed the association of FPRs expression with clinicopathological parameters. The levels of FPRs mRNA, especially those of FPR1, were significantly higher in colorectal tumors than in distant normal tissues and adjacent non-tumor tissues. FPR1 mRNA expression was also associated with tumor serosal infiltration. FPR1 protein expression was both in the colorectal epitheliums and tumor infiltrating neutrophils/macrophages. Furthermore, the functions of FPR1 in tumor invasion and tissue repair were investigated using the CRC cell lines SW480 and HT29. Higher cell surface expression of FPR1 is associated with significantly increased migration in SW480 cells compared with HT29 cells that have less FPR1 membrane expression. Finally, genetic deletion of fpr1 increased the survival rate of the resulting knockout mice compared with wild type littermates in a mouse model of colitis-associated colorectal cancer. Our data demonstrate that FPR1 may play an important role in tumor cell invasion in CRC patients.
format	article
author	Shu-Qin Li Ning Su Ping Gong Hai-Bo Zhang Jin Liu Ding Wang Yan-Ping Sun Yan Zhang Feng Qian Bo Zhao Yang Yu Richard D. Ye
author_facet	Shu-Qin Li Ning Su Ping Gong Hai-Bo Zhang Jin Liu Ding Wang Yan-Ping Sun Yan Zhang Feng Qian Bo Zhao Yang Yu Richard D. Ye
author_sort	Shu-Qin Li
title	The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer
title_short	The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer
title_full	The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer
title_fullStr	The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer
title_full_unstemmed	The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer
title_sort	expression of formyl peptide receptor 1 is correlated with tumor invasion of human colorectal cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6b7858b479434370b805fc8952c9b037
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The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer

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