The origins and genetic interactions of KRAS mutations are allele- and tissue-specific

The KRAS gene is often mutated at several hotspot codons in cancer, resulting in similar, yet distinct, functional impacts on the KRAS protein. Here, the authors examine the genetic interactions of the different KRAS mutations across multiple cancer types and discover that KRAS mutations have allele...

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Autores principales:	Joshua H. Cook, Giorgio E. M. Melloni, Doga C. Gulhan, Peter J. Park, Kevin M. Haigis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b78dc38cde4474b804ab0f1febede19
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spelling	oai:doaj.org-article:6b78dc38cde4474b804ab0f1febede192021-12-02T14:02:51ZThe origins and genetic interactions of KRAS mutations are allele- and tissue-specific10.1038/s41467-021-22125-z2041-1723https://doaj.org/article/6b78dc38cde4474b804ab0f1febede192021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22125-zhttps://doaj.org/toc/2041-1723The KRAS gene is often mutated at several hotspot codons in cancer, resulting in similar, yet distinct, functional impacts on the KRAS protein. Here, the authors examine the genetic interactions of the different KRAS mutations across multiple cancer types and discover that KRAS mutations have allele- and tissue-specific mutagenic origins, comutation patterns, and dependency interactions.Joshua H. CookGiorgio E. M. MelloniDoga C. GulhanPeter J. ParkKevin M. HaigisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua H. Cook Giorgio E. M. Melloni Doga C. Gulhan Peter J. Park Kevin M. Haigis The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
description	The KRAS gene is often mutated at several hotspot codons in cancer, resulting in similar, yet distinct, functional impacts on the KRAS protein. Here, the authors examine the genetic interactions of the different KRAS mutations across multiple cancer types and discover that KRAS mutations have allele- and tissue-specific mutagenic origins, comutation patterns, and dependency interactions.
format	article
author	Joshua H. Cook Giorgio E. M. Melloni Doga C. Gulhan Peter J. Park Kevin M. Haigis
author_facet	Joshua H. Cook Giorgio E. M. Melloni Doga C. Gulhan Peter J. Park Kevin M. Haigis
author_sort	Joshua H. Cook
title	The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
title_short	The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
title_full	The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
title_fullStr	The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
title_full_unstemmed	The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
title_sort	origins and genetic interactions of kras mutations are allele- and tissue-specific
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b78dc38cde4474b804ab0f1febede19
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The origins and genetic interactions of KRAS mutations are allele- and tissue-specific

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