Antibacterial properties of PEKK for orthopedic applications

Mian Wang,1 Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Orthopedic implant infections hav...

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Autores principales:	Wang M, Bhardwaj G, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	PEKK PEEK orthopedic bacteria infection Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6b7bc3045d36445696c6b321783bfb30
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spelling	oai:doaj.org-article:6b7bc3045d36445696c6b321783bfb302021-12-02T02:40:52ZAntibacterial properties of PEKK for orthopedic applications1178-2013https://doaj.org/article/6b7bc3045d36445696c6b321783bfb302017-09-01T00:00:00Zhttps://www.dovepress.com/antibacterial-properties-of-pekk-for-orthopedic-applications-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mian Wang,1 Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Orthopedic implant infections have been steadily increasing while, at the same time, antibiotics developed to kill such bacteria have proven less and less effective with every passing day. It is clear that new approaches that do not rely on the use of antibiotics are needed to decrease medical device infections. Inspired by cicada wing surface topographical features, nanostructured surfaces represent a new approach for imposing antibacterial properties to biomaterials without using drugs. Moreover, new chemistries with altered surface energetics may decrease bacterial attachment and growth. In this study, a nanostructured surface was fabricated on poly-ether-ketone-ketone (PEKK), a new orthopedic implant chemistry, comprised of nanopillars with random interpillar spacing. Specifically, after 5 days, when compared to the orthopedic industry standard poly-ether-ether-ketone (PEEK), more than 37% less Staphylococcus epidermidis were found on the PEKK surface. Pseudomonas aeruginosa attachment and growth also decreased 28% after one day of culture, with around a 50% decrease after 5 days of culture when compared to PEEK. Such decreases in bacteria function were achieved without using antibiotics. In this manner, this study demonstrated for the first time, the promise that nanostructured PEKK has for numerous anti-infection orthopedic implant applications. Keywords: PEKK, PEEK, orthopedic, bacteria, infectionWang MBhardwaj GWebster TJDove Medical PressarticlePEKKPEEKorthopedicbacteriainfectionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6471-6476 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	PEKK PEEK orthopedic bacteria infection Medicine (General) R5-920
spellingShingle	PEKK PEEK orthopedic bacteria infection Medicine (General) R5-920 Wang M Bhardwaj G Webster TJ Antibacterial properties of PEKK for orthopedic applications
description	Mian Wang,1 Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Orthopedic implant infections have been steadily increasing while, at the same time, antibiotics developed to kill such bacteria have proven less and less effective with every passing day. It is clear that new approaches that do not rely on the use of antibiotics are needed to decrease medical device infections. Inspired by cicada wing surface topographical features, nanostructured surfaces represent a new approach for imposing antibacterial properties to biomaterials without using drugs. Moreover, new chemistries with altered surface energetics may decrease bacterial attachment and growth. In this study, a nanostructured surface was fabricated on poly-ether-ketone-ketone (PEKK), a new orthopedic implant chemistry, comprised of nanopillars with random interpillar spacing. Specifically, after 5 days, when compared to the orthopedic industry standard poly-ether-ether-ketone (PEEK), more than 37% less Staphylococcus epidermidis were found on the PEKK surface. Pseudomonas aeruginosa attachment and growth also decreased 28% after one day of culture, with around a 50% decrease after 5 days of culture when compared to PEEK. Such decreases in bacteria function were achieved without using antibiotics. In this manner, this study demonstrated for the first time, the promise that nanostructured PEKK has for numerous anti-infection orthopedic implant applications. Keywords: PEKK, PEEK, orthopedic, bacteria, infection
format	article
author	Wang M Bhardwaj G Webster TJ
author_facet	Wang M Bhardwaj G Webster TJ
author_sort	Wang M
title	Antibacterial properties of PEKK for orthopedic applications
title_short	Antibacterial properties of PEKK for orthopedic applications
title_full	Antibacterial properties of PEKK for orthopedic applications
title_fullStr	Antibacterial properties of PEKK for orthopedic applications
title_full_unstemmed	Antibacterial properties of PEKK for orthopedic applications
title_sort	antibacterial properties of pekk for orthopedic applications
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/6b7bc3045d36445696c6b321783bfb30
work_keys_str_mv	AT wangm antibacterialpropertiesofpekkfororthopedicapplications AT bhardwajg antibacterialpropertiesofpekkfororthopedicapplications AT webstertj antibacterialpropertiesofpekkfororthopedicapplications
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Antibacterial properties of PEKK for orthopedic applications

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