Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

Activated hepatic stellate cells are associated with fibrosis and liver metastases. Here, the authors identify an endogenous role of relaxin in regulating the activation of hepatic stellate cells and report nanoparticle-mediated relaxin gene therapy to mitigate fibrosis and liver metastasis.

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Autores principales:	Mengying Hu, Ying Wang, Ligeng Xu, Sai An, Yu Tang, Xuefei Zhou, Jingjing Li, Rihe Liu, Leaf Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b82eb1e8cdf47688cd6f310885ad26f
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spelling	oai:doaj.org-article:6b82eb1e8cdf47688cd6f310885ad26f2021-12-02T15:35:50ZRelaxin gene delivery mitigates liver metastasis and synergizes with check point therapy10.1038/s41467-019-10893-82041-1723https://doaj.org/article/6b82eb1e8cdf47688cd6f310885ad26f2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10893-8https://doaj.org/toc/2041-1723Activated hepatic stellate cells are associated with fibrosis and liver metastases. Here, the authors identify an endogenous role of relaxin in regulating the activation of hepatic stellate cells and report nanoparticle-mediated relaxin gene therapy to mitigate fibrosis and liver metastasis.Mengying HuYing WangLigeng XuSai AnYu TangXuefei ZhouJingjing LiRihe LiuLeaf HuangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mengying Hu Ying Wang Ligeng Xu Sai An Yu Tang Xuefei Zhou Jingjing Li Rihe Liu Leaf Huang Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy
description	Activated hepatic stellate cells are associated with fibrosis and liver metastases. Here, the authors identify an endogenous role of relaxin in regulating the activation of hepatic stellate cells and report nanoparticle-mediated relaxin gene therapy to mitigate fibrosis and liver metastasis.
format	article
author	Mengying Hu Ying Wang Ligeng Xu Sai An Yu Tang Xuefei Zhou Jingjing Li Rihe Liu Leaf Huang
author_facet	Mengying Hu Ying Wang Ligeng Xu Sai An Yu Tang Xuefei Zhou Jingjing Li Rihe Liu Leaf Huang
author_sort	Mengying Hu
title	Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy
title_short	Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy
title_full	Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy
title_fullStr	Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy
title_full_unstemmed	Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy
title_sort	relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6b82eb1e8cdf47688cd6f310885ad26f
work_keys_str_mv	AT mengyinghu relaxingenedeliverymitigateslivermetastasisandsynergizeswithcheckpointtherapy AT yingwang relaxingenedeliverymitigateslivermetastasisandsynergizeswithcheckpointtherapy AT ligengxu relaxingenedeliverymitigateslivermetastasisandsynergizeswithcheckpointtherapy AT saian relaxingenedeliverymitigateslivermetastasisandsynergizeswithcheckpointtherapy AT yutang relaxingenedeliverymitigateslivermetastasisandsynergizeswithcheckpointtherapy AT xuefeizhou relaxingenedeliverymitigateslivermetastasisandsynergizeswithcheckpointtherapy AT jingjingli relaxingenedeliverymitigateslivermetastasisandsynergizeswithcheckpointtherapy AT riheliu relaxingenedeliverymitigateslivermetastasisandsynergizeswithcheckpointtherapy AT leafhuang relaxingenedeliverymitigateslivermetastasisandsynergizeswithcheckpointtherapy
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Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

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