Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

Activated hepatic stellate cells are associated with fibrosis and liver metastases. Here, the authors identify an endogenous role of relaxin in regulating the activation of hepatic stellate cells and report nanoparticle-mediated relaxin gene therapy to mitigate fibrosis and liver metastasis.

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Auteurs principaux: Mengying Hu, Ying Wang, Ligeng Xu, Sai An, Yu Tang, Xuefei Zhou, Jingjing Li, Rihe Liu, Leaf Huang
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/6b82eb1e8cdf47688cd6f310885ad26f
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