Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

In contrast to HIV, simian immunodeficiency viruses (SIV) do not cause disease in their hosts, and the reasons for this are unclear. Here, Joas et al. incorporate two putative HIV virulence factors into SIV and study effects in infected monkeys, suggesting that species-specific host factors are resp...

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Autores principales: Simone Joas, Erica H. Parrish, Clement W. Gnanadurai, Edina Lump, Christina M. Stürzel, Nicholas F. Parrish, Gerald H. Learn, Ulrike Sauermann, Berit Neumann, Kerstin Mätz Rensing, Dietmar Fuchs, James M. Billingsley, Steven E. Bosinger, Guido Silvestri, Cristian Apetrei, Nicolas Huot, Thalia Garcia-Tellez, Michaela Müller-Trutwin, Dominik Hotter, Daniel Sauter, Christiane Stahl-Hennig, Beatrice H. Hahn, Frank Kirchhoff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6b840246338c48ae857ef8de0672d11d
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spelling oai:doaj.org-article:6b840246338c48ae857ef8de0672d11d2021-12-02T17:32:33ZSpecies-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity10.1038/s41467-018-03762-32041-1723https://doaj.org/article/6b840246338c48ae857ef8de0672d11d2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03762-3https://doaj.org/toc/2041-1723In contrast to HIV, simian immunodeficiency viruses (SIV) do not cause disease in their hosts, and the reasons for this are unclear. Here, Joas et al. incorporate two putative HIV virulence factors into SIV and study effects in infected monkeys, suggesting that species-specific host factors are responsible for HIV pathogenesis.Simone JoasErica H. ParrishClement W. GnanaduraiEdina LumpChristina M. StürzelNicholas F. ParrishGerald H. LearnUlrike SauermannBerit NeumannKerstin Mätz RensingDietmar FuchsJames M. BillingsleySteven E. BosingerGuido SilvestriCristian ApetreiNicolas HuotThalia Garcia-TellezMichaela Müller-TrutwinDominik HotterDaniel SauterChristiane Stahl-HennigBeatrice H. HahnFrank KirchhoffNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Simone Joas
Erica H. Parrish
Clement W. Gnanadurai
Edina Lump
Christina M. Stürzel
Nicholas F. Parrish
Gerald H. Learn
Ulrike Sauermann
Berit Neumann
Kerstin Mätz Rensing
Dietmar Fuchs
James M. Billingsley
Steven E. Bosinger
Guido Silvestri
Cristian Apetrei
Nicolas Huot
Thalia Garcia-Tellez
Michaela Müller-Trutwin
Dominik Hotter
Daniel Sauter
Christiane Stahl-Hennig
Beatrice H. Hahn
Frank Kirchhoff
Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
description In contrast to HIV, simian immunodeficiency viruses (SIV) do not cause disease in their hosts, and the reasons for this are unclear. Here, Joas et al. incorporate two putative HIV virulence factors into SIV and study effects in infected monkeys, suggesting that species-specific host factors are responsible for HIV pathogenesis.
format article
author Simone Joas
Erica H. Parrish
Clement W. Gnanadurai
Edina Lump
Christina M. Stürzel
Nicholas F. Parrish
Gerald H. Learn
Ulrike Sauermann
Berit Neumann
Kerstin Mätz Rensing
Dietmar Fuchs
James M. Billingsley
Steven E. Bosinger
Guido Silvestri
Cristian Apetrei
Nicolas Huot
Thalia Garcia-Tellez
Michaela Müller-Trutwin
Dominik Hotter
Daniel Sauter
Christiane Stahl-Hennig
Beatrice H. Hahn
Frank Kirchhoff
author_facet Simone Joas
Erica H. Parrish
Clement W. Gnanadurai
Edina Lump
Christina M. Stürzel
Nicholas F. Parrish
Gerald H. Learn
Ulrike Sauermann
Berit Neumann
Kerstin Mätz Rensing
Dietmar Fuchs
James M. Billingsley
Steven E. Bosinger
Guido Silvestri
Cristian Apetrei
Nicolas Huot
Thalia Garcia-Tellez
Michaela Müller-Trutwin
Dominik Hotter
Daniel Sauter
Christiane Stahl-Hennig
Beatrice H. Hahn
Frank Kirchhoff
author_sort Simone Joas
title Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
title_short Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
title_full Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
title_fullStr Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
title_full_unstemmed Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
title_sort species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6b840246338c48ae857ef8de0672d11d
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