Sickle Cell Disease: Thoughts for India From the Jamaican Cohort Study

The sickle cell gene in India represents a separate occurrence of the HbS mutation (the Asian haplotype), which has occurred against a genetic background characterised by high levels of fetal haemoglobin and widely varying frequencies of alpha thalassaemia. These features, which tend to inhibit sick...

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Autor principal:	Graham R. Serjeant
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sickle cell disease Jamaica cohort study India geographic comparison Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6b86d2e6106e4c169c426a2a1d638bb2
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spelling	oai:doaj.org-article:6b86d2e6106e4c169c426a2a1d638bb22021-11-05T13:45:46ZSickle Cell Disease: Thoughts for India From the Jamaican Cohort Study2296-858X10.3389/fmed.2021.745189https://doaj.org/article/6b86d2e6106e4c169c426a2a1d638bb22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.745189/fullhttps://doaj.org/toc/2296-858XThe sickle cell gene in India represents a separate occurrence of the HbS mutation (the Asian haplotype), which has occurred against a genetic background characterised by high levels of fetal haemoglobin and widely varying frequencies of alpha thalassaemia. These features, which tend to inhibit sickling, change the expression of the disease, which, in India, may be further modified by poor nutrition, malaria and other infections, and limited public health resources. Sickle cell disease in Jamaica is predominantly of African origin (the Benin haplotype) and faces some similar challenges. This review assesses similarities and differences between disease expression in the two countries and seeks to explore lessons from Jamaica, which may be relevant to Indian health care. In particular, it addresses common causes of hospital admission as detailed from Indian clinical experience: anemia, bone pain crisis, and infections.Graham R. SerjeantFrontiers Media S.A.articlesickle cell diseaseJamaicacohort studyIndiageographic comparisonMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sickle cell disease Jamaica cohort study India geographic comparison Medicine (General) R5-920
spellingShingle	sickle cell disease Jamaica cohort study India geographic comparison Medicine (General) R5-920 Graham R. Serjeant Sickle Cell Disease: Thoughts for India From the Jamaican Cohort Study
description	The sickle cell gene in India represents a separate occurrence of the HbS mutation (the Asian haplotype), which has occurred against a genetic background characterised by high levels of fetal haemoglobin and widely varying frequencies of alpha thalassaemia. These features, which tend to inhibit sickling, change the expression of the disease, which, in India, may be further modified by poor nutrition, malaria and other infections, and limited public health resources. Sickle cell disease in Jamaica is predominantly of African origin (the Benin haplotype) and faces some similar challenges. This review assesses similarities and differences between disease expression in the two countries and seeks to explore lessons from Jamaica, which may be relevant to Indian health care. In particular, it addresses common causes of hospital admission as detailed from Indian clinical experience: anemia, bone pain crisis, and infections.
format	article
author	Graham R. Serjeant
author_facet	Graham R. Serjeant
author_sort	Graham R. Serjeant
title	Sickle Cell Disease: Thoughts for India From the Jamaican Cohort Study
title_short	Sickle Cell Disease: Thoughts for India From the Jamaican Cohort Study
title_full	Sickle Cell Disease: Thoughts for India From the Jamaican Cohort Study
title_fullStr	Sickle Cell Disease: Thoughts for India From the Jamaican Cohort Study
title_full_unstemmed	Sickle Cell Disease: Thoughts for India From the Jamaican Cohort Study
title_sort	sickle cell disease: thoughts for india from the jamaican cohort study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6b86d2e6106e4c169c426a2a1d638bb2
work_keys_str_mv	AT grahamrserjeant sicklecelldiseasethoughtsforindiafromthejamaicancohortstudy
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Sickle Cell Disease: Thoughts for India From the Jamaican Cohort Study

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