Feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model

Abstract Although endobiliary radiofrequency ablation (RFA) has demonstrated considerable potential for the treatment of biliary strictures, conventional catheter RFA has several limitations. This study aimed to evaluate the feasibility of a novel cholangioscopy (CS)-guided balloon-based RFA procedu...

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Autores principales:	Tadahisa Inoue, Hiromu Kutsumi, Mayu Ibusuki, Masashi Yoneda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b87f8f25eba4717b0d2b1035ce30d59
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spelling	oai:doaj.org-article:6b87f8f25eba4717b0d2b1035ce30d592021-12-02T15:23:16ZFeasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model10.1038/s41598-021-93643-52045-2322https://doaj.org/article/6b87f8f25eba4717b0d2b1035ce30d592021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93643-5https://doaj.org/toc/2045-2322Abstract Although endobiliary radiofrequency ablation (RFA) has demonstrated considerable potential for the treatment of biliary strictures, conventional catheter RFA has several limitations. This study aimed to evaluate the feasibility of a novel cholangioscopy (CS)-guided balloon-based RFA procedure in vivo using a swine model. CS-guided balloon-RFA was performed under endoscopic retrograde cholangiography guidance at target temperatures of 60 ℃ or 70 ℃, which were maintained for 60 s. We evaluated the technical feasibility, adverse events, and histological effects associated with the procedure. Twelve sites were ablated in seven miniature pigs. The CS-guided balloon-RFA procedure was technically successful in all cases without any hindrance. Mucosal changes could be detected during RFA, and the ablation area was identified on CS. Necropsy was performed in four pigs on the same day as the procedure: the tissue samples showed coagulative necrosis, and the entire internal circumference of the bile duct was uniformly ablated. The mean lengths of the ablation area in the samples ablated at 60 °C and 70 °C were 20.64 and 22.18 mm, respectively, while the mean depths were 3.46 and 5.07 mm, respectively. The other three pigs were reared and euthanized and autopsied 35 days after the procedure. The site to be ablated had replaced the granulation tissue and fibrotic changes. No adverse events were observed in any case. CS-guided balloon-RFA appears to be a promising option for treating biliary strictures. This preliminary study could pave the way for the evaluation of this procedure in future human clinical trials.Tadahisa InoueHiromu KutsumiMayu IbusukiMasashi YonedaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tadahisa Inoue Hiromu Kutsumi Mayu Ibusuki Masashi Yoneda Feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model
description	Abstract Although endobiliary radiofrequency ablation (RFA) has demonstrated considerable potential for the treatment of biliary strictures, conventional catheter RFA has several limitations. This study aimed to evaluate the feasibility of a novel cholangioscopy (CS)-guided balloon-based RFA procedure in vivo using a swine model. CS-guided balloon-RFA was performed under endoscopic retrograde cholangiography guidance at target temperatures of 60 ℃ or 70 ℃, which were maintained for 60 s. We evaluated the technical feasibility, adverse events, and histological effects associated with the procedure. Twelve sites were ablated in seven miniature pigs. The CS-guided balloon-RFA procedure was technically successful in all cases without any hindrance. Mucosal changes could be detected during RFA, and the ablation area was identified on CS. Necropsy was performed in four pigs on the same day as the procedure: the tissue samples showed coagulative necrosis, and the entire internal circumference of the bile duct was uniformly ablated. The mean lengths of the ablation area in the samples ablated at 60 °C and 70 °C were 20.64 and 22.18 mm, respectively, while the mean depths were 3.46 and 5.07 mm, respectively. The other three pigs were reared and euthanized and autopsied 35 days after the procedure. The site to be ablated had replaced the granulation tissue and fibrotic changes. No adverse events were observed in any case. CS-guided balloon-RFA appears to be a promising option for treating biliary strictures. This preliminary study could pave the way for the evaluation of this procedure in future human clinical trials.
format	article
author	Tadahisa Inoue Hiromu Kutsumi Mayu Ibusuki Masashi Yoneda
author_facet	Tadahisa Inoue Hiromu Kutsumi Mayu Ibusuki Masashi Yoneda
author_sort	Tadahisa Inoue
title	Feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model
title_short	Feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model
title_full	Feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model
title_fullStr	Feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model
title_full_unstemmed	Feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model
title_sort	feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b87f8f25eba4717b0d2b1035ce30d59
work_keys_str_mv	AT tadahisainoue feasibilityofballoonbasedendobiliaryradiofrequencyablationundercholangioscopyguidanceinaswinemodel AT hiromukutsumi feasibilityofballoonbasedendobiliaryradiofrequencyablationundercholangioscopyguidanceinaswinemodel AT mayuibusuki feasibilityofballoonbasedendobiliaryradiofrequencyablationundercholangioscopyguidanceinaswinemodel AT masashiyoneda feasibilityofballoonbasedendobiliaryradiofrequencyablationundercholangioscopyguidanceinaswinemodel
_version_	1718387269246648320

Feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model

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