Current Concepts of Psoriasis Immunopathogenesis

Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is the most common inflammatory skin disease, affecting an average of 2–4% of the world’s population. The disease ca...

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Autores principales:	Marijana Vičić, Marija Kaštelan, Ines Brajac, Vlatka Sotošek, Larisa Prpić Massari
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	psoriasis etiology immunopathogenesis T lymphocytes dendritic cells keratinocytes Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6b87ff032bfc4d7faff5c7dc1efb6e36
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spelling	oai:doaj.org-article:6b87ff032bfc4d7faff5c7dc1efb6e362021-11-11T17:03:26ZCurrent Concepts of Psoriasis Immunopathogenesis10.3390/ijms2221115741422-00671661-6596https://doaj.org/article/6b87ff032bfc4d7faff5c7dc1efb6e362021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11574https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is the most common inflammatory skin disease, affecting an average of 2–4% of the world’s population. The disease carries a significant burden due to its numerous comorbidities and the major impact on patients’ social and emotional aspects of life. According to current knowledge, psoriasis is a multifactorial disease that occurs in genetically predisposed individuals under various environmental factors, which trigger an immune response disorder with a series of complex inflammatory cascades. The disease is initiated and maintained by mutual interaction of the innate and adaptive immune cells, primarily dendritic cells, T lymphocytes, and keratinocytes, whose leading role alternates at different stages of the disease, consisting mainly in the IL-23/Th17 pathway. Inflammatory events result in consequent epidermal and dermal changes and evolution of the characteristic psoriatic phenotype, respectively. This paper aims to present a comprehensive overview of current knowledge on psoriasis genetic and environmental etiological factors, immunopathogenesis, and the leading cellular and cytokine participants in the inflammatory pathways of this disease.Marijana VičićMarija KaštelanInes BrajacVlatka SotošekLarisa Prpić MassariMDPI AGarticlepsoriasisetiologyimmunopathogenesisT lymphocytesdendritic cellskeratinocytesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11574, p 11574 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis etiology immunopathogenesis T lymphocytes dendritic cells keratinocytes Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	psoriasis etiology immunopathogenesis T lymphocytes dendritic cells keratinocytes Biology (General) QH301-705.5 Chemistry QD1-999 Marijana Vičić Marija Kaštelan Ines Brajac Vlatka Sotošek Larisa Prpić Massari Current Concepts of Psoriasis Immunopathogenesis
description	Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is the most common inflammatory skin disease, affecting an average of 2–4% of the world’s population. The disease carries a significant burden due to its numerous comorbidities and the major impact on patients’ social and emotional aspects of life. According to current knowledge, psoriasis is a multifactorial disease that occurs in genetically predisposed individuals under various environmental factors, which trigger an immune response disorder with a series of complex inflammatory cascades. The disease is initiated and maintained by mutual interaction of the innate and adaptive immune cells, primarily dendritic cells, T lymphocytes, and keratinocytes, whose leading role alternates at different stages of the disease, consisting mainly in the IL-23/Th17 pathway. Inflammatory events result in consequent epidermal and dermal changes and evolution of the characteristic psoriatic phenotype, respectively. This paper aims to present a comprehensive overview of current knowledge on psoriasis genetic and environmental etiological factors, immunopathogenesis, and the leading cellular and cytokine participants in the inflammatory pathways of this disease.
format	article
author	Marijana Vičić Marija Kaštelan Ines Brajac Vlatka Sotošek Larisa Prpić Massari
author_facet	Marijana Vičić Marija Kaštelan Ines Brajac Vlatka Sotošek Larisa Prpić Massari
author_sort	Marijana Vičić
title	Current Concepts of Psoriasis Immunopathogenesis
title_short	Current Concepts of Psoriasis Immunopathogenesis
title_full	Current Concepts of Psoriasis Immunopathogenesis
title_fullStr	Current Concepts of Psoriasis Immunopathogenesis
title_full_unstemmed	Current Concepts of Psoriasis Immunopathogenesis
title_sort	current concepts of psoriasis immunopathogenesis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6b87ff032bfc4d7faff5c7dc1efb6e36
work_keys_str_mv	AT marijanavicic currentconceptsofpsoriasisimmunopathogenesis AT marijakastelan currentconceptsofpsoriasisimmunopathogenesis AT inesbrajac currentconceptsofpsoriasisimmunopathogenesis AT vlatkasotosek currentconceptsofpsoriasisimmunopathogenesis AT larisaprpicmassari currentconceptsofpsoriasisimmunopathogenesis
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Current Concepts of Psoriasis Immunopathogenesis

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