Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis

Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis

Abstract Lumbar spinal canal stenosis (LSS) or mechanical compression of dorsal root ganglion (DRG) is one of the causes of low back pain and neuropathic pain (NP). Lysophosphatidic acid (LPA) is a potent bioactive lipid mediator that is produced mainly from lysophosphatidylcholine (LPC) via autotax...

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Main Authors: Baasanjav Uranbileg, Nobuko Ito, Makoto Kurano, Kuniyuki Kano, Kanji Uchida, Masahiko Sumitani, Junken Aoki, Yutaka Yatomi
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/6b88f183c5dc48c3a8dfbb407525812e
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