Epidemiological and Clinical Features of Primary Giant Cell Tumors of the Distal Radium: A Multicenter Retrospective Study in China
Abstract Giant cell tumors of the distal radius are challenging for surgeons because they are associated with high recurrence rates and poor functional outcomes. Between June 2005 and October 2015, patients with primary giant cell tumors of the distal radius were recruited from seven orthopedic cent...
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2017
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oai:doaj.org-article:6b910699a659404b9864411e6d06fbaa2021-12-02T11:52:14ZEpidemiological and Clinical Features of Primary Giant Cell Tumors of the Distal Radium: A Multicenter Retrospective Study in China10.1038/s41598-017-09486-62045-2322https://doaj.org/article/6b910699a659404b9864411e6d06fbaa2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09486-6https://doaj.org/toc/2045-2322Abstract Giant cell tumors of the distal radius are challenging for surgeons because they are associated with high recurrence rates and poor functional outcomes. Between June 2005 and October 2015, patients with primary giant cell tumors of the distal radius were recruited from seven orthopedic centers in China. The patients’ clinical features and demographic characteristics were obtained from medical records and reviewed retrospectively. Overall, 48 cases of giant cell tumors of the distal radius were assessed in this study. These patients were more likely to be between 20 and 40 years of age, to have a Campanacci grade of III, and to undergo a surgical style of resection. The prevalence of pathological fractures was 12.5% overall (20.0% in men and 4.3% in women). The prevalence of local recurrence was 30.0% overall (38.1% in men and 21.1% in women) during the average follow-up period of 62.5 months, with a pulmonary metastasis rate of 5.0%. Giant cell tumors of the distal radius were predominant in men and were more likely to recur locally than around the knee. These findings suggest that it is crucial to evaluate the optimal surgical approach for balancing local recurrence control and functional outcomes to reduce the disease burden.Hongbin CaoFengsong LinYongcheng HuLiming ZhaoXiuchun YuZhen WangZhaoming YeSujia WuShibing GuoGuochuan ZhangJinghua WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017) |
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Medicine R Science Q Hongbin Cao Fengsong Lin Yongcheng Hu Liming Zhao Xiuchun Yu Zhen Wang Zhaoming Ye Sujia Wu Shibing Guo Guochuan Zhang Jinghua Wang Epidemiological and Clinical Features of Primary Giant Cell Tumors of the Distal Radium: A Multicenter Retrospective Study in China |
| description |
Abstract Giant cell tumors of the distal radius are challenging for surgeons because they are associated with high recurrence rates and poor functional outcomes. Between June 2005 and October 2015, patients with primary giant cell tumors of the distal radius were recruited from seven orthopedic centers in China. The patients’ clinical features and demographic characteristics were obtained from medical records and reviewed retrospectively. Overall, 48 cases of giant cell tumors of the distal radius were assessed in this study. These patients were more likely to be between 20 and 40 years of age, to have a Campanacci grade of III, and to undergo a surgical style of resection. The prevalence of pathological fractures was 12.5% overall (20.0% in men and 4.3% in women). The prevalence of local recurrence was 30.0% overall (38.1% in men and 21.1% in women) during the average follow-up period of 62.5 months, with a pulmonary metastasis rate of 5.0%. Giant cell tumors of the distal radius were predominant in men and were more likely to recur locally than around the knee. These findings suggest that it is crucial to evaluate the optimal surgical approach for balancing local recurrence control and functional outcomes to reduce the disease burden. |
| format |
article |
| author |
Hongbin Cao Fengsong Lin Yongcheng Hu Liming Zhao Xiuchun Yu Zhen Wang Zhaoming Ye Sujia Wu Shibing Guo Guochuan Zhang Jinghua Wang |
| author_facet |
Hongbin Cao Fengsong Lin Yongcheng Hu Liming Zhao Xiuchun Yu Zhen Wang Zhaoming Ye Sujia Wu Shibing Guo Guochuan Zhang Jinghua Wang |
| author_sort |
Hongbin Cao |
| title |
Epidemiological and Clinical Features of Primary Giant Cell Tumors of the Distal Radium: A Multicenter Retrospective Study in China |
| title_short |
Epidemiological and Clinical Features of Primary Giant Cell Tumors of the Distal Radium: A Multicenter Retrospective Study in China |
| title_full |
Epidemiological and Clinical Features of Primary Giant Cell Tumors of the Distal Radium: A Multicenter Retrospective Study in China |
| title_fullStr |
Epidemiological and Clinical Features of Primary Giant Cell Tumors of the Distal Radium: A Multicenter Retrospective Study in China |
| title_full_unstemmed |
Epidemiological and Clinical Features of Primary Giant Cell Tumors of the Distal Radium: A Multicenter Retrospective Study in China |
| title_sort |
epidemiological and clinical features of primary giant cell tumors of the distal radium: a multicenter retrospective study in china |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6b910699a659404b9864411e6d06fbaa |
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