Structure-based redesigning of pentoxifylline analogs against selective phosphodiesterases to modulate sperm functional competence for assisted reproductive technologies

Structure-based redesigning of pentoxifylline analogs against selective phosphodiesterases to modulate sperm functional competence for assisted reproductive technologies

Abstract Phosphodiesterase (PDE) inhibitors, such as pentoxifylline (PTX), are used as pharmacological agents to enhance sperm motility in assisted reproductive technology (ART), mainly to aid the selection of viable sperm in asthenozoospermic ejaculates and testicular spermatozoa, prior to intracyt...

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Autores principales: Mutyala Satish, Sandhya Kumari, Waghela Deeksha, Suman Abhishek, Kulhar Nitin, Satish Kumar Adiga, Padmaraj Hegde, Jagadeesh Prasad Dasappa, Guruprasad Kalthur, Eerappa Rajakumara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6b92d4ccba4c4906872030c4e4ff86cb
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