Collagen cross-linking: Strengthening the unstable cornea

Oren Tomkins, Hanna J GarzoziDepartment of Ophthalmology, Bnai Zion Medical Center, Haifa, IsraelAbstract: Corneal ectasia, a weakening of corneal integrity, occurs both due to acquired and congenital conditions such as keratoconus. It is a progressing condition that affects both visual acuity, and...

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Autores principales:	Oren Tomkins, Hanna J Garzozi
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6b93b4dd05fd4735888c2ed33e03d1c8
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spelling	oai:doaj.org-article:6b93b4dd05fd4735888c2ed33e03d1c82021-12-02T02:02:42ZCollagen cross-linking: Strengthening the unstable cornea1177-54671177-5483https://doaj.org/article/6b93b4dd05fd4735888c2ed33e03d1c82008-05-01T00:00:00Zhttp://www.dovepress.com/collagen-cross-linking-strengthening-the-unstable-cornea-a420https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Oren Tomkins, Hanna J GarzoziDepartment of Ophthalmology, Bnai Zion Medical Center, Haifa, IsraelAbstract: Corneal ectasia, a weakening of corneal integrity, occurs both due to acquired and congenital conditions such as keratoconus. It is a progressing condition that affects both visual acuity, and corneal stability. Various methods exist for correcting this impairment, however none address the inherit pathology, an increase laxity of the corneal stroma. Collagen crosslinking, a new, minimally invasive method, aims to strengthen the stroma by inducing cross links between neighboring collagen fibers. This method results in an increase in corneal tensile strength, with no medium term adverse effects on its normal architecture. Clinically, treated patients display improvement in both visual acuity and keratometric readings. This method may provide clinicians with easily accessible tools to stop the progression, and even correct visual deterioration due to corneal ectasia. Here we review the current information regarding this new method, as well as discuss its potential benefits and downfalls.Keywords: corneal cross-linking, corneal ectasia, keratoconus, stroma, cornea Oren TomkinsHanna J GarzoziDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 4, Pp 863-867 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Oren Tomkins Hanna J Garzozi Collagen cross-linking: Strengthening the unstable cornea
description	Oren Tomkins, Hanna J GarzoziDepartment of Ophthalmology, Bnai Zion Medical Center, Haifa, IsraelAbstract: Corneal ectasia, a weakening of corneal integrity, occurs both due to acquired and congenital conditions such as keratoconus. It is a progressing condition that affects both visual acuity, and corneal stability. Various methods exist for correcting this impairment, however none address the inherit pathology, an increase laxity of the corneal stroma. Collagen crosslinking, a new, minimally invasive method, aims to strengthen the stroma by inducing cross links between neighboring collagen fibers. This method results in an increase in corneal tensile strength, with no medium term adverse effects on its normal architecture. Clinically, treated patients display improvement in both visual acuity and keratometric readings. This method may provide clinicians with easily accessible tools to stop the progression, and even correct visual deterioration due to corneal ectasia. Here we review the current information regarding this new method, as well as discuss its potential benefits and downfalls.Keywords: corneal cross-linking, corneal ectasia, keratoconus, stroma, cornea
format	article
author	Oren Tomkins Hanna J Garzozi
author_facet	Oren Tomkins Hanna J Garzozi
author_sort	Oren Tomkins
title	Collagen cross-linking: Strengthening the unstable cornea
title_short	Collagen cross-linking: Strengthening the unstable cornea
title_full	Collagen cross-linking: Strengthening the unstable cornea
title_fullStr	Collagen cross-linking: Strengthening the unstable cornea
title_full_unstemmed	Collagen cross-linking: Strengthening the unstable cornea
title_sort	collagen cross-linking: strengthening the unstable cornea
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/6b93b4dd05fd4735888c2ed33e03d1c8
work_keys_str_mv	AT orentomkins collagencrosslinkingstrengtheningtheunstablecornea AT hannajgarzozi collagencrosslinkingstrengtheningtheunstablecornea
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Collagen cross-linking: Strengthening the unstable cornea

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