A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses
Vaccines for SARS-COV-2 are needed in the ongoing pandemic. Here the authors characterize a vaccine candidate that presents the receptor-binding domain (RBD) of SARS-CoV-2 spike protein on a synthetic VLP platform using SpyTag/SpyCatcher technology and show immunogenicity of a prime-boost regimen in...
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Nature Portfolio
2021
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oai:doaj.org-article:6b95639b85804b348dfe9af334fe3bcf2021-12-02T13:56:46ZA COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses10.1038/s41467-020-20654-72041-1723https://doaj.org/article/6b95639b85804b348dfe9af334fe3bcf2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20654-7https://doaj.org/toc/2041-1723Vaccines for SARS-COV-2 are needed in the ongoing pandemic. Here the authors characterize a vaccine candidate that presents the receptor-binding domain (RBD) of SARS-CoV-2 spike protein on a synthetic VLP platform using SpyTag/SpyCatcher technology and show immunogenicity of a prime-boost regimen in mice and pigs.Tiong Kit TanPramila RijalRolle RahikainenAnthony H. KeebleLisa SchimanskiSaira HussainRuth HarveyJack W. P. HayesJane C. EdwardsRebecca K. McLeanVeronica MartiniMiriam PedreraNazia ThakurCarina ConceicaoIsabelle DietrichHolly SheltonAnna LudiGinette WilsdenClare BrowningAdrian K. ZagrajekDagmara BialySushant BhatPhoebe Stevenson-LeggettPhilippa HollinghurstMatthew TullyKaty MoffatChris ChiuRyan WatersAshley GrayMehreen AzharValerie MiouletJoseph NewmanAmin S. AsforAlison BurmanSylvia CrossleyJohn A. HammondElma TchilianBryan CharlestonDalan BaileyTobias J. TuthillSimon P. GrahamHelen M. E. DuyvesteynTomas MalinauskasJiandong HuoJulia A. TreeKaren R. ButtigiegRaymond J. OwensMiles W. CarrollRodney S. DanielsJohn W. McCauleyDavid I. StuartKuan-Ying A. HuangMark HowarthAlain R. TownsendNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Tiong Kit Tan Pramila Rijal Rolle Rahikainen Anthony H. Keeble Lisa Schimanski Saira Hussain Ruth Harvey Jack W. P. Hayes Jane C. Edwards Rebecca K. McLean Veronica Martini Miriam Pedrera Nazia Thakur Carina Conceicao Isabelle Dietrich Holly Shelton Anna Ludi Ginette Wilsden Clare Browning Adrian K. Zagrajek Dagmara Bialy Sushant Bhat Phoebe Stevenson-Leggett Philippa Hollinghurst Matthew Tully Katy Moffat Chris Chiu Ryan Waters Ashley Gray Mehreen Azhar Valerie Mioulet Joseph Newman Amin S. Asfor Alison Burman Sylvia Crossley John A. Hammond Elma Tchilian Bryan Charleston Dalan Bailey Tobias J. Tuthill Simon P. Graham Helen M. E. Duyvesteyn Tomas Malinauskas Jiandong Huo Julia A. Tree Karen R. Buttigieg Raymond J. Owens Miles W. Carroll Rodney S. Daniels John W. McCauley David I. Stuart Kuan-Ying A. Huang Mark Howarth Alain R. Townsend A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses |
| description |
Vaccines for SARS-COV-2 are needed in the ongoing pandemic. Here the authors characterize a vaccine candidate that presents the receptor-binding domain (RBD) of SARS-CoV-2 spike protein on a synthetic VLP platform using SpyTag/SpyCatcher technology and show immunogenicity of a prime-boost regimen in mice and pigs. |
| format |
article |
| author |
Tiong Kit Tan Pramila Rijal Rolle Rahikainen Anthony H. Keeble Lisa Schimanski Saira Hussain Ruth Harvey Jack W. P. Hayes Jane C. Edwards Rebecca K. McLean Veronica Martini Miriam Pedrera Nazia Thakur Carina Conceicao Isabelle Dietrich Holly Shelton Anna Ludi Ginette Wilsden Clare Browning Adrian K. Zagrajek Dagmara Bialy Sushant Bhat Phoebe Stevenson-Leggett Philippa Hollinghurst Matthew Tully Katy Moffat Chris Chiu Ryan Waters Ashley Gray Mehreen Azhar Valerie Mioulet Joseph Newman Amin S. Asfor Alison Burman Sylvia Crossley John A. Hammond Elma Tchilian Bryan Charleston Dalan Bailey Tobias J. Tuthill Simon P. Graham Helen M. E. Duyvesteyn Tomas Malinauskas Jiandong Huo Julia A. Tree Karen R. Buttigieg Raymond J. Owens Miles W. Carroll Rodney S. Daniels John W. McCauley David I. Stuart Kuan-Ying A. Huang Mark Howarth Alain R. Townsend |
| author_facet |
Tiong Kit Tan Pramila Rijal Rolle Rahikainen Anthony H. Keeble Lisa Schimanski Saira Hussain Ruth Harvey Jack W. P. Hayes Jane C. Edwards Rebecca K. McLean Veronica Martini Miriam Pedrera Nazia Thakur Carina Conceicao Isabelle Dietrich Holly Shelton Anna Ludi Ginette Wilsden Clare Browning Adrian K. Zagrajek Dagmara Bialy Sushant Bhat Phoebe Stevenson-Leggett Philippa Hollinghurst Matthew Tully Katy Moffat Chris Chiu Ryan Waters Ashley Gray Mehreen Azhar Valerie Mioulet Joseph Newman Amin S. Asfor Alison Burman Sylvia Crossley John A. Hammond Elma Tchilian Bryan Charleston Dalan Bailey Tobias J. Tuthill Simon P. Graham Helen M. E. Duyvesteyn Tomas Malinauskas Jiandong Huo Julia A. Tree Karen R. Buttigieg Raymond J. Owens Miles W. Carroll Rodney S. Daniels John W. McCauley David I. Stuart Kuan-Ying A. Huang Mark Howarth Alain R. Townsend |
| author_sort |
Tiong Kit Tan |
| title |
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses |
| title_short |
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses |
| title_full |
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses |
| title_fullStr |
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses |
| title_full_unstemmed |
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses |
| title_sort |
covid-19 vaccine candidate using spycatcher multimerization of the sars-cov-2 spike protein receptor-binding domain induces potent neutralising antibody responses |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6b95639b85804b348dfe9af334fe3bcf |
| work_keys_str_mv |
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