Simulation of angiogenesis in three dimensions: Application to cerebral cortex.

The vasculature is a dynamic structure, growing and regressing in response to embryonic development, growth, changing physiological demands, wound healing, tumor growth and other stimuli. At the microvascular level, network geometry is not predetermined, but emerges as a result of biological respons...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jonathan P Alberding, Timothy W Secomb
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6b9694e5a64c4af28973f0eefe475373
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6b9694e5a64c4af28973f0eefe475373
record_format	dspace
spelling	oai:doaj.org-article:6b9694e5a64c4af28973f0eefe4753732021-11-25T05:40:34ZSimulation of angiogenesis in three dimensions: Application to cerebral cortex.1553-734X1553-735810.1371/journal.pcbi.1009164https://doaj.org/article/6b9694e5a64c4af28973f0eefe4753732021-06-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009164https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The vasculature is a dynamic structure, growing and regressing in response to embryonic development, growth, changing physiological demands, wound healing, tumor growth and other stimuli. At the microvascular level, network geometry is not predetermined, but emerges as a result of biological responses of each vessel to the stimuli that it receives. These responses may be summarized as angiogenesis, remodeling and pruning. Previous theoretical simulations have shown how two-dimensional vascular patterns generated by these processes in the mesentery are consistent with experimental observations. During early development of the brain, a mesh-like network of vessels is formed on the surface of the cerebral cortex. This network then forms branches into the cortex, forming a three-dimensional network throughout its thickness. Here, a theoretical model is presented for this process, based on known or hypothesized vascular response mechanisms together with experimentally obtained information on the structure and hemodynamics of the mouse cerebral cortex. According to this model, essential components of the system include sensing of oxygen levels in the midrange of partial pressures and conducted responses in vessel walls that propagate information about metabolic needs of the tissue to upstream segments of the network. The model provides insights into the effects of deficits in vascular response mechanisms, and can be used to generate physiologically realistic microvascular network structures.Jonathan P AlberdingTimothy W SecombPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 6, p e1009164 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jonathan P Alberding Timothy W Secomb Simulation of angiogenesis in three dimensions: Application to cerebral cortex.
description	The vasculature is a dynamic structure, growing and regressing in response to embryonic development, growth, changing physiological demands, wound healing, tumor growth and other stimuli. At the microvascular level, network geometry is not predetermined, but emerges as a result of biological responses of each vessel to the stimuli that it receives. These responses may be summarized as angiogenesis, remodeling and pruning. Previous theoretical simulations have shown how two-dimensional vascular patterns generated by these processes in the mesentery are consistent with experimental observations. During early development of the brain, a mesh-like network of vessels is formed on the surface of the cerebral cortex. This network then forms branches into the cortex, forming a three-dimensional network throughout its thickness. Here, a theoretical model is presented for this process, based on known or hypothesized vascular response mechanisms together with experimentally obtained information on the structure and hemodynamics of the mouse cerebral cortex. According to this model, essential components of the system include sensing of oxygen levels in the midrange of partial pressures and conducted responses in vessel walls that propagate information about metabolic needs of the tissue to upstream segments of the network. The model provides insights into the effects of deficits in vascular response mechanisms, and can be used to generate physiologically realistic microvascular network structures.
format	article
author	Jonathan P Alberding Timothy W Secomb
author_facet	Jonathan P Alberding Timothy W Secomb
author_sort	Jonathan P Alberding
title	Simulation of angiogenesis in three dimensions: Application to cerebral cortex.
title_short	Simulation of angiogenesis in three dimensions: Application to cerebral cortex.
title_full	Simulation of angiogenesis in three dimensions: Application to cerebral cortex.
title_fullStr	Simulation of angiogenesis in three dimensions: Application to cerebral cortex.
title_full_unstemmed	Simulation of angiogenesis in three dimensions: Application to cerebral cortex.
title_sort	simulation of angiogenesis in three dimensions: application to cerebral cortex.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6b9694e5a64c4af28973f0eefe475373
work_keys_str_mv	AT jonathanpalberding simulationofangiogenesisinthreedimensionsapplicationtocerebralcortex AT timothywsecomb simulationofangiogenesisinthreedimensionsapplicationtocerebralcortex
_version_	1718414522253836288

Simulation of angiogenesis in three dimensions: Application to cerebral cortex.

Ejemplares similares