Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials

Abstract Here, we report that the development of a brain-to-brain interface (BBI) system that enables a human user to manipulate rat movement without any previous training. In our model, the remotely-guided rats (known as ratbots) successfully navigated a T-maze via contralateral turning behaviour i...

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Autores principales:	Bonkon Koo, Chin Su Koh, Hae-Yong Park, Hwan-Gon Lee, Jin Woo Chang, Seungjin Choi, Hyung-Cheul Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b96bdb942574228aae6cc0fab0d8fb0
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spelling	oai:doaj.org-article:6b96bdb942574228aae6cc0fab0d8fb02021-12-02T12:30:13ZManipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials10.1038/s41598-017-02521-62045-2322https://doaj.org/article/6b96bdb942574228aae6cc0fab0d8fb02017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02521-6https://doaj.org/toc/2045-2322Abstract Here, we report that the development of a brain-to-brain interface (BBI) system that enables a human user to manipulate rat movement without any previous training. In our model, the remotely-guided rats (known as ratbots) successfully navigated a T-maze via contralateral turning behaviour induced by electrical stimulation of the nigrostriatal (NS) pathway by a brain- computer interface (BCI) based on the human controller’s steady-state visually evoked potentials (SSVEPs). The system allowed human participants to manipulate rat movement with an average success rate of 82.2% and at an average rat speed of approximately 1.9 m/min. The ratbots had no directional preference, showing average success rates of 81.1% and 83.3% for the left- and right-turning task, respectively. This is the first study to demonstrate the use of NS stimulation for developing a highly stable ratbot that does not require previous training, and is the first instance of a training-free BBI for rat navigation. The results of this study will facilitate the development of borderless communication between human and untrained animals, which could not only improve the understanding of animals in humans, but also allow untrained animals to more effectively provide humans with information obtained with their superior perception.Bonkon KooChin Su KohHae-Yong ParkHwan-Gon LeeJin Woo ChangSeungjin ChoiHyung-Cheul ShinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bonkon Koo Chin Su Koh Hae-Yong Park Hwan-Gon Lee Jin Woo Chang Seungjin Choi Hyung-Cheul Shin Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials
description	Abstract Here, we report that the development of a brain-to-brain interface (BBI) system that enables a human user to manipulate rat movement without any previous training. In our model, the remotely-guided rats (known as ratbots) successfully navigated a T-maze via contralateral turning behaviour induced by electrical stimulation of the nigrostriatal (NS) pathway by a brain- computer interface (BCI) based on the human controller’s steady-state visually evoked potentials (SSVEPs). The system allowed human participants to manipulate rat movement with an average success rate of 82.2% and at an average rat speed of approximately 1.9 m/min. The ratbots had no directional preference, showing average success rates of 81.1% and 83.3% for the left- and right-turning task, respectively. This is the first study to demonstrate the use of NS stimulation for developing a highly stable ratbot that does not require previous training, and is the first instance of a training-free BBI for rat navigation. The results of this study will facilitate the development of borderless communication between human and untrained animals, which could not only improve the understanding of animals in humans, but also allow untrained animals to more effectively provide humans with information obtained with their superior perception.
format	article
author	Bonkon Koo Chin Su Koh Hae-Yong Park Hwan-Gon Lee Jin Woo Chang Seungjin Choi Hyung-Cheul Shin
author_facet	Bonkon Koo Chin Su Koh Hae-Yong Park Hwan-Gon Lee Jin Woo Chang Seungjin Choi Hyung-Cheul Shin
author_sort	Bonkon Koo
title	Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials
title_short	Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials
title_full	Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials
title_fullStr	Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials
title_full_unstemmed	Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials
title_sort	manipulation of rat movement via nigrostriatal stimulation controlled by human visually evoked potentials
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6b96bdb942574228aae6cc0fab0d8fb0
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Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials

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