Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs

Abstract Complete removal of cancerous tissue and preservation of breast cosmesis with a single breast conserving surgery (BCS) is essential for surgeons. New and better options would allow them to more consistently achieve this goal and expand the number of women that receive this preferred therapy...

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Autores principales:	Theodore J. Puls, Carla S. Fisher, Abigail Cox, Jeannie M. Plantenga, Emma L. McBride, Jennifer L. Anderson, Craig J. Goergen, Melissa Bible, Tracy Moller, Sherry L. Voytik-Harbin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b99293e2113474ca5776bc2823bfbaf
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spelling	oai:doaj.org-article:6b99293e2113474ca5776bc2823bfbaf2021-12-02T10:44:21ZRegenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs10.1038/s41598-021-81771-x2045-2322https://doaj.org/article/6b99293e2113474ca5776bc2823bfbaf2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81771-xhttps://doaj.org/toc/2045-2322Abstract Complete removal of cancerous tissue and preservation of breast cosmesis with a single breast conserving surgery (BCS) is essential for surgeons. New and better options would allow them to more consistently achieve this goal and expand the number of women that receive this preferred therapy, while minimizing the need for re-excision and revision procedures or more aggressive surgical approaches (i.e., mastectomy). We have developed and evaluated a regenerative tissue filler that is applied as a liquid to defects during BCS prior to transitioning to a fibrillar collagen scaffold with soft tissue consistency. Using a porcine simulated BCS model, the collagen filler was shown to induce a regenerative healing response, characterized by rapid cellularization, vascularization, and progressive breast tissue neogenesis, including adipose tissue and mammary glands and ducts. Unlike conventional biomaterials, no foreign body response or inflammatory-mediated “active” biodegradation was observed. The collagen filler also did not compromise simulated surgical re-excision, radiography, or ultrasonography procedures, features that are important for clinical translation. When post-BCS radiation was applied, the collagen filler and its associated tissue response were largely similar to non-irradiated conditions; however, as expected, healing was modestly slower. This in situ scaffold-forming collagen is easy to apply, conforms to patient-specific defects, and regenerates complex soft tissues in the absence of inflammation. It has significant translational potential as the first regenerative tissue filler for BCS as well as other soft tissue restoration and reconstruction needs.Theodore J. PulsCarla S. FisherAbigail CoxJeannie M. PlantengaEmma L. McBrideJennifer L. AndersonCraig J. GoergenMelissa BibleTracy MollerSherry L. Voytik-HarbinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Theodore J. Puls Carla S. Fisher Abigail Cox Jeannie M. Plantenga Emma L. McBride Jennifer L. Anderson Craig J. Goergen Melissa Bible Tracy Moller Sherry L. Voytik-Harbin Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs
description	Abstract Complete removal of cancerous tissue and preservation of breast cosmesis with a single breast conserving surgery (BCS) is essential for surgeons. New and better options would allow them to more consistently achieve this goal and expand the number of women that receive this preferred therapy, while minimizing the need for re-excision and revision procedures or more aggressive surgical approaches (i.e., mastectomy). We have developed and evaluated a regenerative tissue filler that is applied as a liquid to defects during BCS prior to transitioning to a fibrillar collagen scaffold with soft tissue consistency. Using a porcine simulated BCS model, the collagen filler was shown to induce a regenerative healing response, characterized by rapid cellularization, vascularization, and progressive breast tissue neogenesis, including adipose tissue and mammary glands and ducts. Unlike conventional biomaterials, no foreign body response or inflammatory-mediated “active” biodegradation was observed. The collagen filler also did not compromise simulated surgical re-excision, radiography, or ultrasonography procedures, features that are important for clinical translation. When post-BCS radiation was applied, the collagen filler and its associated tissue response were largely similar to non-irradiated conditions; however, as expected, healing was modestly slower. This in situ scaffold-forming collagen is easy to apply, conforms to patient-specific defects, and regenerates complex soft tissues in the absence of inflammation. It has significant translational potential as the first regenerative tissue filler for BCS as well as other soft tissue restoration and reconstruction needs.
format	article
author	Theodore J. Puls Carla S. Fisher Abigail Cox Jeannie M. Plantenga Emma L. McBride Jennifer L. Anderson Craig J. Goergen Melissa Bible Tracy Moller Sherry L. Voytik-Harbin
author_facet	Theodore J. Puls Carla S. Fisher Abigail Cox Jeannie M. Plantenga Emma L. McBride Jennifer L. Anderson Craig J. Goergen Melissa Bible Tracy Moller Sherry L. Voytik-Harbin
author_sort	Theodore J. Puls
title	Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs
title_short	Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs
title_full	Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs
title_fullStr	Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs
title_full_unstemmed	Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs
title_sort	regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b99293e2113474ca5776bc2823bfbaf
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Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs

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