Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance With Treatment, Reluctance to Return to School

Objective: The SARS-CoV-2 pandemic has induced an exceptional sanitary crisis, potentially having an impact on treatment continuation, for juvenile idiopathic arthritis (JIA) patients receiving immunosuppressive therapies. After national lockdowns, many patients were also concerned about their safet...

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Autores principales:	Baptiste Quéré, Irene Lemelle, Anne Lohse, Pascal Pillet, Julie Molimard, Olivier Richer, Christelle Sordet, Véronique Despert, Linda Rossi-Semerano, Charlotte Borocco, Isabelle Kone-Paut, Elisabeth Gervais, Dewi Guellec, Valérie Devauchelle-Pensec
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	juvenile idiopathic arthritis COVID-19 compliance treatment DMARDs school Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6b994409f15049c9ad94b6bf94f53da7
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spelling	oai:doaj.org-article:6b994409f15049c9ad94b6bf94f53da72021-11-12T04:41:32ZJuvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance With Treatment, Reluctance to Return to School2296-858X10.3389/fmed.2021.743815https://doaj.org/article/6b994409f15049c9ad94b6bf94f53da72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.743815/fullhttps://doaj.org/toc/2296-858XObjective: The SARS-CoV-2 pandemic has induced an exceptional sanitary crisis, potentially having an impact on treatment continuation, for juvenile idiopathic arthritis (JIA) patients receiving immunosuppressive therapies. After national lockdowns, many patients were also concerned about their safety at school. We evaluated the impact of the pandemic on the optimal continuation of treatment and on the return to school in JIA patients.Methods: JIA patients under 18 years of age, usually treated with disease-modifying anti-rheumatic drugs (DMARDs) were prospectively included during their outpatient visit and completed a standardized questionnaire. The primary outcome was DMARD treatment modification in relation to the context of the pandemic but we also evaluated the pandemic's impact on the schooling.Results: One hundred and seventy three patients from 8 different expert centers were included between May and August 2020. Their mean age was 11.6 years (± 4.1 years), and most of them 31.2% (54/173) had a rheumatoid factor-negative polyarticular JIA. Fifty percent (86/172) were treated with methotrexate, and 72.5% (124/171) were treated with bDMARDs. DMARD treatment modification in relation to the pandemic was observed in 4.0% (7/173) of participants. 49.1% (81/165) of the patients did not return to school due to a personal/parental decision in 69.9% (55/81) of cases. Two patients were diagnosed positive for SARS-CoV-2 infection.Conclusion: This study suggests that JIA patients treated with DMARDs continued their treatment during the pandemic and were rarely affected by symptomatic COVID-19. In contrast, parents' reluctance was a major obstacle for returning to school. Therefore, more solidified school reopening strategies should be developed.Baptiste QuéréIrene LemelleAnne LohsePascal PilletJulie MolimardOlivier RicherChristelle SordetVéronique DespertLinda Rossi-SemeranoCharlotte BoroccoIsabelle Kone-PautElisabeth GervaisDewi GuellecValérie Devauchelle-PensecFrontiers Media S.A.articlejuvenile idiopathic arthritisCOVID-19compliancetreatmentDMARDsschoolMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	juvenile idiopathic arthritis COVID-19 compliance treatment DMARDs school Medicine (General) R5-920
spellingShingle	juvenile idiopathic arthritis COVID-19 compliance treatment DMARDs school Medicine (General) R5-920 Baptiste Quéré Irene Lemelle Anne Lohse Pascal Pillet Julie Molimard Olivier Richer Christelle Sordet Véronique Despert Linda Rossi-Semerano Charlotte Borocco Isabelle Kone-Paut Elisabeth Gervais Dewi Guellec Valérie Devauchelle-Pensec Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance With Treatment, Reluctance to Return to School
description	Objective: The SARS-CoV-2 pandemic has induced an exceptional sanitary crisis, potentially having an impact on treatment continuation, for juvenile idiopathic arthritis (JIA) patients receiving immunosuppressive therapies. After national lockdowns, many patients were also concerned about their safety at school. We evaluated the impact of the pandemic on the optimal continuation of treatment and on the return to school in JIA patients.Methods: JIA patients under 18 years of age, usually treated with disease-modifying anti-rheumatic drugs (DMARDs) were prospectively included during their outpatient visit and completed a standardized questionnaire. The primary outcome was DMARD treatment modification in relation to the context of the pandemic but we also evaluated the pandemic's impact on the schooling.Results: One hundred and seventy three patients from 8 different expert centers were included between May and August 2020. Their mean age was 11.6 years (± 4.1 years), and most of them 31.2% (54/173) had a rheumatoid factor-negative polyarticular JIA. Fifty percent (86/172) were treated with methotrexate, and 72.5% (124/171) were treated with bDMARDs. DMARD treatment modification in relation to the pandemic was observed in 4.0% (7/173) of participants. 49.1% (81/165) of the patients did not return to school due to a personal/parental decision in 69.9% (55/81) of cases. Two patients were diagnosed positive for SARS-CoV-2 infection.Conclusion: This study suggests that JIA patients treated with DMARDs continued their treatment during the pandemic and were rarely affected by symptomatic COVID-19. In contrast, parents' reluctance was a major obstacle for returning to school. Therefore, more solidified school reopening strategies should be developed.
format	article
author	Baptiste Quéré Irene Lemelle Anne Lohse Pascal Pillet Julie Molimard Olivier Richer Christelle Sordet Véronique Despert Linda Rossi-Semerano Charlotte Borocco Isabelle Kone-Paut Elisabeth Gervais Dewi Guellec Valérie Devauchelle-Pensec
author_facet	Baptiste Quéré Irene Lemelle Anne Lohse Pascal Pillet Julie Molimard Olivier Richer Christelle Sordet Véronique Despert Linda Rossi-Semerano Charlotte Borocco Isabelle Kone-Paut Elisabeth Gervais Dewi Guellec Valérie Devauchelle-Pensec
author_sort	Baptiste Quéré
title	Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance With Treatment, Reluctance to Return to School
title_short	Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance With Treatment, Reluctance to Return to School
title_full	Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance With Treatment, Reluctance to Return to School
title_fullStr	Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance With Treatment, Reluctance to Return to School
title_full_unstemmed	Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance With Treatment, Reluctance to Return to School
title_sort	juvenile idiopathic arthritis and covid-19 pandemic: good compliance with treatment, reluctance to return to school
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6b994409f15049c9ad94b6bf94f53da7
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Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance With Treatment, Reluctance to Return to School

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