From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review

Background: Focused Ultrasound (FUS) is gaining a therapeutic role in neuro-oncology considering its novelty and non-invasiveness. Multiple pre-clinical studies show the efficacy of FUS mediated ablation and Blood-Brain Barrier (BBB) opening in high-grade glioma (HGG), but there is still poor eviden...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Luca Paun, Alessandro Moiraghi, Gianpaolo Jannelli, Aria Nouri, Francesco DiMeco, Johan Pallud, Torstein R. Meling, Shahan Momjian, Karl Schaller, Francesco Prada, Denis Migliorini
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	focused ultrasound high grade glioma glioblastoma brain-blood barrier opening tumor ablation ultrasound Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6b9b383cc60e481c82eefe2d06d959cf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6b9b383cc60e481c82eefe2d06d959cf
record_format	dspace
spelling	oai:doaj.org-article:6b9b383cc60e481c82eefe2d06d959cf2021-11-25T17:01:37ZFrom Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review10.3390/cancers132256142072-6694https://doaj.org/article/6b9b383cc60e481c82eefe2d06d959cf2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5614https://doaj.org/toc/2072-6694Background: Focused Ultrasound (FUS) is gaining a therapeutic role in neuro-oncology considering its novelty and non-invasiveness. Multiple pre-clinical studies show the efficacy of FUS mediated ablation and Blood-Brain Barrier (BBB) opening in high-grade glioma (HGG), but there is still poor evidence in humans, mainly aimed towards assessing FUS safety. Methods: With this systematic review our aim is, firstly, to summarize how FUS is proposed for human HGG treatment. Secondly, we focus on future perspectives and new therapeutic options. Using PRISMA 2020 guidelines, we reviewed case series and trials with description of patient characteristics, pre- and post-operative treatments and FUS outcomes. We considered nine case series (five about tumor ablation and four about BBB opening) with FUS-treated HGG patients between 1991 and 2021. Results: Sixty-eight patients were considered in total, mostly males (67.6%), with a mean age of 50.5 ± 15.3 years old. Major complication rates were found in the tumor ablation group (26.1%). FUS has been rarely applied for direct tumoral ablation in human HGG patients with controversial results, but at the best of current studies, FUS-mediated BBB opening is showing good results with very low complication rates, paving the way for a new reliable technique to improve local chemotherapy delivery and antitumoral immune response. Conclusions: FUS can become a complementary technique to surgical resection and standard radiochemotherapy in recurrent HGG. Ongoing trials could provide in the near future more data on FUS-mediated BBB opening impact on progression-free survival, overall survival and potential drug-delivery capacities.Luca PaunAlessandro MoiraghiGianpaolo JannelliAria NouriFrancesco DiMecoJohan PalludTorstein R. MelingShahan MomjianKarl SchallerFrancesco PradaDenis MiglioriniMDPI AGarticlefocused ultrasoundhigh grade gliomaglioblastomabrain-blood barrier openingtumor ablationultrasoundNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5614, p 5614 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	focused ultrasound high grade glioma glioblastoma brain-blood barrier opening tumor ablation ultrasound Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	focused ultrasound high grade glioma glioblastoma brain-blood barrier opening tumor ablation ultrasound Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Luca Paun Alessandro Moiraghi Gianpaolo Jannelli Aria Nouri Francesco DiMeco Johan Pallud Torstein R. Meling Shahan Momjian Karl Schaller Francesco Prada Denis Migliorini From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review
description	Background: Focused Ultrasound (FUS) is gaining a therapeutic role in neuro-oncology considering its novelty and non-invasiveness. Multiple pre-clinical studies show the efficacy of FUS mediated ablation and Blood-Brain Barrier (BBB) opening in high-grade glioma (HGG), but there is still poor evidence in humans, mainly aimed towards assessing FUS safety. Methods: With this systematic review our aim is, firstly, to summarize how FUS is proposed for human HGG treatment. Secondly, we focus on future perspectives and new therapeutic options. Using PRISMA 2020 guidelines, we reviewed case series and trials with description of patient characteristics, pre- and post-operative treatments and FUS outcomes. We considered nine case series (five about tumor ablation and four about BBB opening) with FUS-treated HGG patients between 1991 and 2021. Results: Sixty-eight patients were considered in total, mostly males (67.6%), with a mean age of 50.5 ± 15.3 years old. Major complication rates were found in the tumor ablation group (26.1%). FUS has been rarely applied for direct tumoral ablation in human HGG patients with controversial results, but at the best of current studies, FUS-mediated BBB opening is showing good results with very low complication rates, paving the way for a new reliable technique to improve local chemotherapy delivery and antitumoral immune response. Conclusions: FUS can become a complementary technique to surgical resection and standard radiochemotherapy in recurrent HGG. Ongoing trials could provide in the near future more data on FUS-mediated BBB opening impact on progression-free survival, overall survival and potential drug-delivery capacities.
format	article
author	Luca Paun Alessandro Moiraghi Gianpaolo Jannelli Aria Nouri Francesco DiMeco Johan Pallud Torstein R. Meling Shahan Momjian Karl Schaller Francesco Prada Denis Migliorini
author_facet	Luca Paun Alessandro Moiraghi Gianpaolo Jannelli Aria Nouri Francesco DiMeco Johan Pallud Torstein R. Meling Shahan Momjian Karl Schaller Francesco Prada Denis Migliorini
author_sort	Luca Paun
title	From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review
title_short	From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review
title_full	From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review
title_fullStr	From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review
title_full_unstemmed	From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review
title_sort	from focused ultrasound tumor ablation to brain blood barrier opening for high grade glioma: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6b9b383cc60e481c82eefe2d06d959cf
work_keys_str_mv	AT lucapaun fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT alessandromoiraghi fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT gianpaolojannelli fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT arianouri fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT francescodimeco fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT johanpallud fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT torsteinrmeling fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT shahanmomjian fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT karlschaller fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT francescoprada fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview AT denismigliorini fromfocusedultrasoundtumorablationtobrainbloodbarrieropeningforhighgradegliomaasystematicreview
_version_	1718412780897304576

From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review

Ejemplares similares