Development of a novel niosomal system for oral delivery of Ginkgo biloba extract

Ye Jin,1,4 Jingyuan Wen,2 Sanjay Garg,3 Da Liu,1 Yulin Zhou,1 Lirong Teng,1,* Weiyu Zhang,4,*1College of Life Science, Jilin University, Jilin, People&rsquo;s Republic of China; 2School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 3Schoo...

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Autores principales:	Jin Y, Wen JY, Garg S, Liu D, Zhou YL, Teng LR, Zhang WY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6b9fb9d240ca410497d8ab37ffa1e09c
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spelling	oai:doaj.org-article:6b9fb9d240ca410497d8ab37ffa1e09c2021-12-02T07:45:58ZDevelopment of a novel niosomal system for oral delivery of Ginkgo biloba extract1176-91141178-2013https://doaj.org/article/6b9fb9d240ca410497d8ab37ffa1e09c2013-01-01T00:00:00Zhttp://www.dovepress.com/development-of-a-novel-niosomal-system-for-oral-delivery-of-ginkgo-bil-a12062https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ye Jin,1,4 Jingyuan Wen,2 Sanjay Garg,3 Da Liu,1 Yulin Zhou,1 Lirong Teng,1,* Weiyu Zhang,4,1College of Life Science, Jilin University, Jilin, People&rsquo;s Republic of China; 2School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 3School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia; 4School of Pharmacy, Changchun University of Chinese Medicine, Jilin, People&rsquo;s Republic of China These authors contributed equally to this workBackground: The aim of this study was to develop an optimal niosomal system to deliver Ginkgo biloba extract (GbE) with improved oral bioavailability and to replace the conventional GbE tablets.Methods: In this study, the film dispersion-homogenization method was used to prepare GbE niosomes. The resulting GbE niosome suspension was freeze-dried or spray-dried to improve the stability of the niosomes. GbE-loaded niosomes were formulated and characterized in terms of their morphology, particle size, zeta potential, entrapment efficiency, and angle of repose, and differential scanning calorimetry analysis was performed. In vitro release and in vivo distribution studies were also carried out.Results: The particle size of the optimal delivery system prepared with Tween 80, Span 80, and cholesterol was about 141 nm. There was a significant difference (P &lt; 0.05) in drug entrapment efficiency between the spray-drying method (about 77.5%) and the freeze-drying method (about 50.1%). The stability study revealed no significant change in drug entrapment efficiency for the GbE niosomes at 4&deg;C and 25&deg;C after 3 months. The in vitro release study suggested that GbE niosomes can prolong the release of flavonoid glycosides in phosphate-buffered solution (pH 6.8) for up to 48 hours. The in vivo distribution study showed that the flavonoid glycoside content in the heart, lung, kidney, brain, and blood of rats treated with the GbE niosome carrier system was greater than in the rats treated with the oral GbE tablet (P &lt; 0.01). No flavonoid glycosides were detected in the brain tissue of rats given the oral GbE tablets, but they were detected in the brain tissue of rats given the GbE niosomes.Conclusion: Niosomes are a promising oral system for delivery of GbE to the brain.Keywords: Ginkgo biloba extract, flavonoid glycosides, niosomes, oral delivery, in vivo distributionJin YWen JYGarg SLiu DZhou YLTeng LRZhang WYDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 421-430 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jin Y Wen JY Garg S Liu D Zhou YL Teng LR Zhang WY Development of a novel niosomal system for oral delivery of Ginkgo biloba extract
description	Ye Jin,1,4 Jingyuan Wen,2 Sanjay Garg,3 Da Liu,1 Yulin Zhou,1 Lirong Teng,1,* Weiyu Zhang,4,1College of Life Science, Jilin University, Jilin, People&rsquo;s Republic of China; 2School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 3School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia; 4School of Pharmacy, Changchun University of Chinese Medicine, Jilin, People&rsquo;s Republic of China These authors contributed equally to this workBackground: The aim of this study was to develop an optimal niosomal system to deliver Ginkgo biloba extract (GbE) with improved oral bioavailability and to replace the conventional GbE tablets.Methods: In this study, the film dispersion-homogenization method was used to prepare GbE niosomes. The resulting GbE niosome suspension was freeze-dried or spray-dried to improve the stability of the niosomes. GbE-loaded niosomes were formulated and characterized in terms of their morphology, particle size, zeta potential, entrapment efficiency, and angle of repose, and differential scanning calorimetry analysis was performed. In vitro release and in vivo distribution studies were also carried out.Results: The particle size of the optimal delivery system prepared with Tween 80, Span 80, and cholesterol was about 141 nm. There was a significant difference (P &lt; 0.05) in drug entrapment efficiency between the spray-drying method (about 77.5%) and the freeze-drying method (about 50.1%). The stability study revealed no significant change in drug entrapment efficiency for the GbE niosomes at 4&deg;C and 25&deg;C after 3 months. The in vitro release study suggested that GbE niosomes can prolong the release of flavonoid glycosides in phosphate-buffered solution (pH 6.8) for up to 48 hours. The in vivo distribution study showed that the flavonoid glycoside content in the heart, lung, kidney, brain, and blood of rats treated with the GbE niosome carrier system was greater than in the rats treated with the oral GbE tablet (P &lt; 0.01). No flavonoid glycosides were detected in the brain tissue of rats given the oral GbE tablets, but they were detected in the brain tissue of rats given the GbE niosomes.Conclusion: Niosomes are a promising oral system for delivery of GbE to the brain.Keywords: Ginkgo biloba extract, flavonoid glycosides, niosomes, oral delivery, in vivo distribution
format	article
author	Jin Y Wen JY Garg S Liu D Zhou YL Teng LR Zhang WY
author_facet	Jin Y Wen JY Garg S Liu D Zhou YL Teng LR Zhang WY
author_sort	Jin Y
title	Development of a novel niosomal system for oral delivery of Ginkgo biloba extract
title_short	Development of a novel niosomal system for oral delivery of Ginkgo biloba extract
title_full	Development of a novel niosomal system for oral delivery of Ginkgo biloba extract
title_fullStr	Development of a novel niosomal system for oral delivery of Ginkgo biloba extract
title_full_unstemmed	Development of a novel niosomal system for oral delivery of Ginkgo biloba extract
title_sort	development of a novel niosomal system for oral delivery of ginkgo biloba extract
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/6b9fb9d240ca410497d8ab37ffa1e09c
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Development of a novel niosomal system for oral delivery of Ginkgo biloba extract

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