Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years

Milk thistle [Silybum marianum (L.) Gaertn.], a member of Asteraceae family, is one of the most cultivated medicinal plants widespread throughout the world. The pharmacological drug is a ripe fruit without pappus – Silybi mariani fructus – containing flavonolignans and generating silymarin complex....

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Autores principales:	Habán M., Zvercová D., Adamjaková M.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	silybum marianum silymarin complex hplc Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6ba2532d237f4fa494fbd34a0ff2e438
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spelling	oai:doaj.org-article:6ba2532d237f4fa494fbd34a0ff2e4382021-12-05T14:11:05ZEvaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years2453-672510.2478/afpuc-2020-0023https://doaj.org/article/6ba2532d237f4fa494fbd34a0ff2e4382021-07-01T00:00:00Zhttps://doi.org/10.2478/afpuc-2020-0023https://doaj.org/toc/2453-6725Milk thistle [Silybum marianum (L.) Gaertn.], a member of Asteraceae family, is one of the most cultivated medicinal plants widespread throughout the world. The pharmacological drug is a ripe fruit without pappus – Silybi mariani fructus – containing flavonolignans and generating silymarin complex. In folk medicine, it is used for the treatment of liver disorders, kidney problems, rheumatism as well as gastronomic disturbances, cardiac and neurotic disorders, and fever. The components of silymarin complex are useful in cancer prevention and treatment. The aim of the study was to determine the amount of silymarin complex contained in the fruit of the harvest of two consecutive years and how much they differ from one another. Representative samples of fruit were collected in 2015 and 2016 and distributed by a company Agrofos (Slovakia). Regarding the analytical method, we used a high-performance liquid chromatography (HPLC); the method was approved by the European Pharmacopoeia 10. The statistical significance was on the level P < 0.05. The total content of silymarin complex was 15.28 ± 0.06 g.kg−1 (in 2015) and 16.65 ± 0.09 g.kg−1 (in 2016). In both studied years, the highest representation of silybin B was observed (7.04 ± 0.07 g.kg−1 versus 5.92 ± 0.08 g.kg−1). The differences between the individual fractions of the silymarin complex were statistically significant. There was also a significant difference of 9% in the total silymarin content between 2015 and 2016. In conclusion, we can state that both samples of Silybi mariani fructus meet the requirements of the European Pharmacopoeia.Habán M.Zvercová D.Adamjaková M.Sciendoarticlesilybum marianumsilymarin complexhplcTherapeutics. PharmacologyRM1-950ENEuropean Pharmaceutical Journal, Vol 68, Iss 1, Pp 40-45 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	silybum marianum silymarin complex hplc Therapeutics. Pharmacology RM1-950
spellingShingle	silybum marianum silymarin complex hplc Therapeutics. Pharmacology RM1-950 Habán M. Zvercová D. Adamjaková M. Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years
description	Milk thistle [Silybum marianum (L.) Gaertn.], a member of Asteraceae family, is one of the most cultivated medicinal plants widespread throughout the world. The pharmacological drug is a ripe fruit without pappus – Silybi mariani fructus – containing flavonolignans and generating silymarin complex. In folk medicine, it is used for the treatment of liver disorders, kidney problems, rheumatism as well as gastronomic disturbances, cardiac and neurotic disorders, and fever. The components of silymarin complex are useful in cancer prevention and treatment. The aim of the study was to determine the amount of silymarin complex contained in the fruit of the harvest of two consecutive years and how much they differ from one another. Representative samples of fruit were collected in 2015 and 2016 and distributed by a company Agrofos (Slovakia). Regarding the analytical method, we used a high-performance liquid chromatography (HPLC); the method was approved by the European Pharmacopoeia 10. The statistical significance was on the level P < 0.05. The total content of silymarin complex was 15.28 ± 0.06 g.kg−1 (in 2015) and 16.65 ± 0.09 g.kg−1 (in 2016). In both studied years, the highest representation of silybin B was observed (7.04 ± 0.07 g.kg−1 versus 5.92 ± 0.08 g.kg−1). The differences between the individual fractions of the silymarin complex were statistically significant. There was also a significant difference of 9% in the total silymarin content between 2015 and 2016. In conclusion, we can state that both samples of Silybi mariani fructus meet the requirements of the European Pharmacopoeia.
format	article
author	Habán M. Zvercová D. Adamjaková M.
author_facet	Habán M. Zvercová D. Adamjaková M.
author_sort	Habán M.
title	Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years
title_short	Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years
title_full	Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years
title_fullStr	Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years
title_full_unstemmed	Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years
title_sort	evaluation of variability of silymarin complex in silybi mariani fructus harvested during two production years
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/6ba2532d237f4fa494fbd34a0ff2e438
work_keys_str_mv	AT habanm evaluationofvariabilityofsilymarincomplexinsilybimarianifructusharvestedduringtwoproductionyears AT zvercovad evaluationofvariabilityofsilymarincomplexinsilybimarianifructusharvestedduringtwoproductionyears AT adamjakovam evaluationofvariabilityofsilymarincomplexinsilybimarianifructusharvestedduringtwoproductionyears
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Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years

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