The hippocampus remains activated over the long term for the retrieval of truly episodic memories.

The role of the hippocampus in declarative memory consolidation is a matter of intense debate. We investigated the neural substrates of memory retrieval for recent and remote information using functional magnetic resonance imaging (fMRI). 18 young, healthy participants learned a series of pictures....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Caroline Harand, Françoise Bertran, Renaud La Joie, Brigitte Landeau, Florence Mézenge, Béatrice Desgranges, Philippe Peigneux, Francis Eustache, Géraldine Rauchs
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ba79e5eb25f45dc9e2c325fed5fcf63
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6ba79e5eb25f45dc9e2c325fed5fcf63
record_format	dspace
spelling	oai:doaj.org-article:6ba79e5eb25f45dc9e2c325fed5fcf632021-11-18T07:07:45ZThe hippocampus remains activated over the long term for the retrieval of truly episodic memories.1932-620310.1371/journal.pone.0043495https://doaj.org/article/6ba79e5eb25f45dc9e2c325fed5fcf632012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22937055/?tool=EBIhttps://doaj.org/toc/1932-6203The role of the hippocampus in declarative memory consolidation is a matter of intense debate. We investigated the neural substrates of memory retrieval for recent and remote information using functional magnetic resonance imaging (fMRI). 18 young, healthy participants learned a series of pictures. Then, during two fMRI recognition sessions, 3 days and 3 months later, they had to determine whether they recognized or not each picture using the "Remember/Know" procedure. Presentation of the same learned images at both delays allowed us to track the evolution of memories and distinguish consistently episodic memories from those that were initially episodic and then became familiar or semantic over time and were retrieved without any contextual detail. Hippocampal activation decreased over time for initially episodic, later semantic memories, but remained stable for consistently episodic ones, at least in its posterior part. For both types of memories, neocortical activations were observed at both delays, notably in the ventromedial prefrontal and anterior cingulate cortices. These activations may reflect a gradual reorganization of memory traces within neural networks. Our data indicate maintenance and strengthening of hippocampal and cortico-cortical connections in the consolidation and retrieval of episodic memories over time, in line with the Multiple Trace theory (Nadel and Moscovitch, 1997). At variance, memories becoming semantic over time consolidate through strengthening of cortico-cortical connections and progressive disengagement of the hippocampus.Caroline HarandFrançoise BertranRenaud La JoieBrigitte LandeauFlorence MézengeBéatrice DesgrangesPhilippe PeigneuxFrancis EustacheGéraldine RauchsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43495 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caroline Harand Françoise Bertran Renaud La Joie Brigitte Landeau Florence Mézenge Béatrice Desgranges Philippe Peigneux Francis Eustache Géraldine Rauchs The hippocampus remains activated over the long term for the retrieval of truly episodic memories.
description	The role of the hippocampus in declarative memory consolidation is a matter of intense debate. We investigated the neural substrates of memory retrieval for recent and remote information using functional magnetic resonance imaging (fMRI). 18 young, healthy participants learned a series of pictures. Then, during two fMRI recognition sessions, 3 days and 3 months later, they had to determine whether they recognized or not each picture using the "Remember/Know" procedure. Presentation of the same learned images at both delays allowed us to track the evolution of memories and distinguish consistently episodic memories from those that were initially episodic and then became familiar or semantic over time and were retrieved without any contextual detail. Hippocampal activation decreased over time for initially episodic, later semantic memories, but remained stable for consistently episodic ones, at least in its posterior part. For both types of memories, neocortical activations were observed at both delays, notably in the ventromedial prefrontal and anterior cingulate cortices. These activations may reflect a gradual reorganization of memory traces within neural networks. Our data indicate maintenance and strengthening of hippocampal and cortico-cortical connections in the consolidation and retrieval of episodic memories over time, in line with the Multiple Trace theory (Nadel and Moscovitch, 1997). At variance, memories becoming semantic over time consolidate through strengthening of cortico-cortical connections and progressive disengagement of the hippocampus.
format	article
author	Caroline Harand Françoise Bertran Renaud La Joie Brigitte Landeau Florence Mézenge Béatrice Desgranges Philippe Peigneux Francis Eustache Géraldine Rauchs
author_facet	Caroline Harand Françoise Bertran Renaud La Joie Brigitte Landeau Florence Mézenge Béatrice Desgranges Philippe Peigneux Francis Eustache Géraldine Rauchs
author_sort	Caroline Harand
title	The hippocampus remains activated over the long term for the retrieval of truly episodic memories.
title_short	The hippocampus remains activated over the long term for the retrieval of truly episodic memories.
title_full	The hippocampus remains activated over the long term for the retrieval of truly episodic memories.
title_fullStr	The hippocampus remains activated over the long term for the retrieval of truly episodic memories.
title_full_unstemmed	The hippocampus remains activated over the long term for the retrieval of truly episodic memories.
title_sort	hippocampus remains activated over the long term for the retrieval of truly episodic memories.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6ba79e5eb25f45dc9e2c325fed5fcf63
work_keys_str_mv	AT carolineharand thehippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT francoisebertran thehippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT renaudlajoie thehippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT brigittelandeau thehippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT florencemezenge thehippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT beatricedesgranges thehippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT philippepeigneux thehippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT franciseustache thehippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT geraldinerauchs thehippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT carolineharand hippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT francoisebertran hippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT renaudlajoie hippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT brigittelandeau hippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT florencemezenge hippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT beatricedesgranges hippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT philippepeigneux hippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT franciseustache hippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories AT geraldinerauchs hippocampusremainsactivatedoverthelongtermfortheretrievaloftrulyepisodicmemories
_version_	1718423920400400384

The hippocampus remains activated over the long term for the retrieval of truly episodic memories.

Ejemplares similares