CROSSREACTIVE ANTIBODIES AND MEMORY T CELLS TO HUMAN AND ZOONOTIC INFLUENZA A VIRUSES IN VOLUNTEERS

There exists a real hazard of transferring zoonotic influenza A viruses, either swine, or avian, into human population. In such case, severity of such pandemics depends on the pathogen-specific immunity in the population. Virtual absence of such immunity in humans was declared in the literature. In...

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Autores principales:	I. V. Losev, S. A. Donina, G. D. Petukhova, D. A. Korenkov, E. P. Grigorieva, E. M. Doroshenko, L. G. Rudenko, A. N. Naykhin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	influenza virus live vaccine immunization heterosubtypic immunity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6bab271b4d8f4bfca4092401973ac37d
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spelling	oai:doaj.org-article:6bab271b4d8f4bfca4092401973ac37d2021-11-18T08:03:45ZCROSSREACTIVE ANTIBODIES AND MEMORY T CELLS TO HUMAN AND ZOONOTIC INFLUENZA A VIRUSES IN VOLUNTEERS1563-06252313-741X10.15789/1563-0625-2015-4-347-358https://doaj.org/article/6bab271b4d8f4bfca4092401973ac37d2015-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/927https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThere exists a real hazard of transferring zoonotic influenza A viruses, either swine, or avian, into human population. In such case, severity of such pandemics depends on the pathogen-specific immunity in the population. Virtual absence of such immunity in humans was declared in the literature. In this work, we assessed systemic, local, and T-cell immunity to potentially pandemic H3N2sw, H5N1, H5N2, H7N3, H7N9 and H2N2 influenza A viruses in a group of healthy adults of different age. Our results indicate that these subjects develop the following immune reactions: (i) local (i.e., nasal IgA) and cellular (CD4+ and CD8v memory T cells) heterosubtypic immunity, in absence of detectable virus-specific serum antibodies to avian influenza A viruses; (ii) Local immune responses (as nasal IgA) to human A (H2N2) virus which circulated in 1957-1968 were detected both in subjects who could be primed at that time, but also in subjects born after 1968; (iii) full-scale systemic and local immunity to potentially pandemic А (H3N2sw) swine virus was found in the group. Conclusion. In order of proper epidemiological forecasts and planning appropriate preventive measures for potentially pandemic Influenza A viruses, a regular monitoring of collective immunity should be performed using different adaptive markers. In this respect, any conclusion based on molecular analysis only could lead to considerable mistakes, and should be accomplished by the mentioned immunological studies.I. V. LosevS. A. DoninaG. D. PetukhovaD. A. KorenkovE. P. GrigorievaE. M. DoroshenkoL. G. RudenkoA. N. NaykhinSPb RAACIarticleinfluenza viruslive vaccineimmunizationheterosubtypic immunityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 4, Pp 347-358 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	influenza virus live vaccine immunization heterosubtypic immunity Immunologic diseases. Allergy RC581-607
spellingShingle	influenza virus live vaccine immunization heterosubtypic immunity Immunologic diseases. Allergy RC581-607 I. V. Losev S. A. Donina G. D. Petukhova D. A. Korenkov E. P. Grigorieva E. M. Doroshenko L. G. Rudenko A. N. Naykhin CROSSREACTIVE ANTIBODIES AND MEMORY T CELLS TO HUMAN AND ZOONOTIC INFLUENZA A VIRUSES IN VOLUNTEERS
description	There exists a real hazard of transferring zoonotic influenza A viruses, either swine, or avian, into human population. In such case, severity of such pandemics depends on the pathogen-specific immunity in the population. Virtual absence of such immunity in humans was declared in the literature. In this work, we assessed systemic, local, and T-cell immunity to potentially pandemic H3N2sw, H5N1, H5N2, H7N3, H7N9 and H2N2 influenza A viruses in a group of healthy adults of different age. Our results indicate that these subjects develop the following immune reactions: (i) local (i.e., nasal IgA) and cellular (CD4+ and CD8v memory T cells) heterosubtypic immunity, in absence of detectable virus-specific serum antibodies to avian influenza A viruses; (ii) Local immune responses (as nasal IgA) to human A (H2N2) virus which circulated in 1957-1968 were detected both in subjects who could be primed at that time, but also in subjects born after 1968; (iii) full-scale systemic and local immunity to potentially pandemic А (H3N2sw) swine virus was found in the group. Conclusion. In order of proper epidemiological forecasts and planning appropriate preventive measures for potentially pandemic Influenza A viruses, a regular monitoring of collective immunity should be performed using different adaptive markers. In this respect, any conclusion based on molecular analysis only could lead to considerable mistakes, and should be accomplished by the mentioned immunological studies.
format	article
author	I. V. Losev S. A. Donina G. D. Petukhova D. A. Korenkov E. P. Grigorieva E. M. Doroshenko L. G. Rudenko A. N. Naykhin
author_facet	I. V. Losev S. A. Donina G. D. Petukhova D. A. Korenkov E. P. Grigorieva E. M. Doroshenko L. G. Rudenko A. N. Naykhin
author_sort	I. V. Losev
title	CROSSREACTIVE ANTIBODIES AND MEMORY T CELLS TO HUMAN AND ZOONOTIC INFLUENZA A VIRUSES IN VOLUNTEERS
title_short	CROSSREACTIVE ANTIBODIES AND MEMORY T CELLS TO HUMAN AND ZOONOTIC INFLUENZA A VIRUSES IN VOLUNTEERS
title_full	CROSSREACTIVE ANTIBODIES AND MEMORY T CELLS TO HUMAN AND ZOONOTIC INFLUENZA A VIRUSES IN VOLUNTEERS
title_fullStr	CROSSREACTIVE ANTIBODIES AND MEMORY T CELLS TO HUMAN AND ZOONOTIC INFLUENZA A VIRUSES IN VOLUNTEERS
title_full_unstemmed	CROSSREACTIVE ANTIBODIES AND MEMORY T CELLS TO HUMAN AND ZOONOTIC INFLUENZA A VIRUSES IN VOLUNTEERS
title_sort	crossreactive antibodies and memory t cells to human and zoonotic influenza a viruses in volunteers
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/6bab271b4d8f4bfca4092401973ac37d
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_version_	1718422423991222272

CROSSREACTIVE ANTIBODIES AND MEMORY T CELLS TO HUMAN AND ZOONOTIC INFLUENZA A VIRUSES IN VOLUNTEERS

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