The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]

We present a genome assembly and annotation of an individual female Cercopithifilaria johnstoni, a parasitic filarial nematode that is transmitted by hard ticks (Ixodidae) to infect a broad range of native Australian murid and marsupial hosts. The genome sequence is 76.9 Mbp in length, and although...

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Autores principales:	Kirsty McCann, Warwick Grant, Stephen R. Doyle
Formato:	article
Lenguaje:	EN
Publicado:	Wellcome 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6baee879389c4a84a790cd20210bd27f
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spelling	oai:doaj.org-article:6baee879389c4a84a790cd20210bd27f2021-11-08T10:54:12ZThe genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]2398-502X10.12688/wellcomeopenres.17258.1https://doaj.org/article/6baee879389c4a84a790cd20210bd27f2021-10-01T00:00:00Zhttps://wellcomeopenresearch.org/articles/6-259/v1https://doaj.org/toc/2398-502XWe present a genome assembly and annotation of an individual female Cercopithifilaria johnstoni, a parasitic filarial nematode that is transmitted by hard ticks (Ixodidae) to infect a broad range of native Australian murid and marsupial hosts. The genome sequence is 76.9 Mbp in length, and although in draft form (N50 = 99 kbp, N50[n] = 232), is largely complete based on universally conserved orthologs (BUSCOs; genome = 94.9%, protein = 96.5%) and relative to other related filarial species. These data represent the first genomic resources for the genus Cercopithifilaria, a group of parasites with a broad host range, and form the basis for comparative analysis with the human-infective parasite, Onchocerca volvulus, both of which are responsible for similar eye and skin pathologies in their respective hosts.Kirsty McCannWarwick GrantStephen R. DoyleWellcomearticleMedicineRScienceQENWellcome Open Research, Vol 6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kirsty McCann Warwick Grant Stephen R. Doyle The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]
description	We present a genome assembly and annotation of an individual female Cercopithifilaria johnstoni, a parasitic filarial nematode that is transmitted by hard ticks (Ixodidae) to infect a broad range of native Australian murid and marsupial hosts. The genome sequence is 76.9 Mbp in length, and although in draft form (N50 = 99 kbp, N50[n] = 232), is largely complete based on universally conserved orthologs (BUSCOs; genome = 94.9%, protein = 96.5%) and relative to other related filarial species. These data represent the first genomic resources for the genus Cercopithifilaria, a group of parasites with a broad host range, and form the basis for comparative analysis with the human-infective parasite, Onchocerca volvulus, both of which are responsible for similar eye and skin pathologies in their respective hosts.
format	article
author	Kirsty McCann Warwick Grant Stephen R. Doyle
author_facet	Kirsty McCann Warwick Grant Stephen R. Doyle
author_sort	Kirsty McCann
title	The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]
title_short	The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]
title_full	The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]
title_fullStr	The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]
title_full_unstemmed	The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]
title_sort	genome sequence of the australian filarial nematode, cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]
publisher	Wellcome
publishDate	2021
url	https://doaj.org/article/6baee879389c4a84a790cd20210bd27f
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The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni [version 1; peer review: 1 approved, 2 approved with reservations]

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