Itopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy

Aim. Evaluation of the itopride (Ganaton?, Abbot) therapy efficacy in the management of gastrointestinal (GI) symptoms and gastric motor function (GMF) in type 1 diabetis mellitus (T1DM) patients (pts) in the presence of GMF dysfunction and other forms of diabetic autonomic neuropathy (DAN). Materi...

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Autores principales:	Irina Yur’evna Budennaya, Irina Vladimirovna Glinkina, Aleksey Vadimovich Zilov, Valeriy Mikhaylovich Makhov, Galina Afanas'evna Mel'nichenko
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	diabetes mellitus gastric motor function gastrointestinal symptoms breath test itopride Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/6bb25c7caf804a2d8692ec707221cf9f
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spelling	oai:doaj.org-article:6bb25c7caf804a2d8692ec707221cf9f2021-11-14T09:00:19ZItopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy2072-03512072-037810.14341/DM2014370-76https://doaj.org/article/6bb25c7caf804a2d8692ec707221cf9f2014-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6441https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. Evaluation of the itopride (Ganaton?, Abbot) therapy efficacy in the management of gastrointestinal (GI) symptoms and gastric motor function (GMF) in type 1 diabetis mellitus (T1DM) patients (pts) in the presence of GMF dysfunction and other forms of diabetic autonomic neuropathy (DAN). Materials and Methods. The total of 34 patients with T1DM, GMF dysfunction and DAN were selected for randomized, prospective, open-label, comparative study. The duration of the study was 6 weeks. The study group (17 pts) received itopride 150 mg total daily. The control group (17 pts) did not receive any treatment for GMF. А questionnaire was used for the assessment of gastrointestinal (GI) symptoms. Gastric emptying velocity was evaluated with 13C-octanoate breath test. Results. As a result of itopride therapy there was a statistically significant decrease in the amount of time (T1/2) needed for the gastric emptying. The median amount of time decreased from 89.0 [82.3; 101.0] min to 53.0 [82.3; 101.0] min (pIrina Yur’evna BudennayaIrina Vladimirovna GlinkinaAleksey Vadimovich ZilovValeriy Mikhaylovich MakhovGalina Afanas'evna Mel'nichenkoEndocrinology Research Centrearticlediabetes mellitusgastric motor functiongastrointestinal symptomsbreath testitoprideNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 3, Pp 70-76 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus gastric motor function gastrointestinal symptoms breath test itopride Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus gastric motor function gastrointestinal symptoms breath test itopride Nutritional diseases. Deficiency diseases RC620-627 Irina Yur’evna Budennaya Irina Vladimirovna Glinkina Aleksey Vadimovich Zilov Valeriy Mikhaylovich Makhov Galina Afanas'evna Mel'nichenko Itopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy
description	Aim. Evaluation of the itopride (Ganaton?, Abbot) therapy efficacy in the management of gastrointestinal (GI) symptoms and gastric motor function (GMF) in type 1 diabetis mellitus (T1DM) patients (pts) in the presence of GMF dysfunction and other forms of diabetic autonomic neuropathy (DAN). Materials and Methods. The total of 34 patients with T1DM, GMF dysfunction and DAN were selected for randomized, prospective, open-label, comparative study. The duration of the study was 6 weeks. The study group (17 pts) received itopride 150 mg total daily. The control group (17 pts) did not receive any treatment for GMF. А questionnaire was used for the assessment of gastrointestinal (GI) symptoms. Gastric emptying velocity was evaluated with 13C-octanoate breath test. Results. As a result of itopride therapy there was a statistically significant decrease in the amount of time (T1/2) needed for the gastric emptying. The median amount of time decreased from 89.0 [82.3; 101.0] min to 53.0 [82.3; 101.0] min (p
format	article
author	Irina Yur’evna Budennaya Irina Vladimirovna Glinkina Aleksey Vadimovich Zilov Valeriy Mikhaylovich Makhov Galina Afanas'evna Mel'nichenko
author_facet	Irina Yur’evna Budennaya Irina Vladimirovna Glinkina Aleksey Vadimovich Zilov Valeriy Mikhaylovich Makhov Galina Afanas'evna Mel'nichenko
author_sort	Irina Yur’evna Budennaya
title	Itopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy
title_short	Itopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy
title_full	Itopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy
title_fullStr	Itopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy
title_full_unstemmed	Itopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy
title_sort	itopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/6bb25c7caf804a2d8692ec707221cf9f
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Itopride hydrochloride efficacy in the management of delayed gastric emptying in type 1 diabetis mellitus patients in the presence of autonomic neuropathy

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