Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?

We describe an unusual case of severe and chronic insomnia that proved to be eminently treatable. Initially presumed to be of primary psychiatric/toxicological origin, certain clinical and paraclinical clues led us to the diagnosis of NMDA-receptor encephalitis, an immune-mediated disease of the bra...

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Autores principales:	Wietse A. Wiels, Yacine Boudiba, Laura Seynaeve, Sylvie De Raedt
Formato:	article
Lenguaje:	EN
Publicado:	Brazilian Association of Sleep and Latin American Federation of Sleep Societies 2021
Materias:	anti-nmda-receptor encephalitis insomnia immune-mediated encephalopathy limbic encephalitis Psychology BF1-990 Consciousness. Cognition BF309-499
Acceso en línea:	https://doaj.org/article/6bb33498eecf4e5687c609fbbe5b8519
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spelling	oai:doaj.org-article:6bb33498eecf4e5687c609fbbe5b85192021-11-24T12:26:11ZAnti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?1984-06591984-0063001610.5935/1984-0063.20200080https://doaj.org/article/6bb33498eecf4e5687c609fbbe5b85192021-10-01T00:00:00Zhttps://www.sleepscience.org.br/details/2931/en-US/anti-nmda-receptor-encephalitis--an-unusual-treatable-cause-of-chronic-insomnia-https://doaj.org/toc/1984-0659https://doaj.org/toc/1984-0063We describe an unusual case of severe and chronic insomnia that proved to be eminently treatable. Initially presumed to be of primary psychiatric/toxicological origin, certain clinical and paraclinical clues led us to the diagnosis of NMDA-receptor encephalitis, an immune-mediated disease of the brain. Our patient responded dramatically to immunotherapy, effectively regaining normal sleep habits and significantly improving his general and mental health after 25 years of insomnia and drug abuse. Immune-mediated encephalopathies should be considered in the differential diagnosis of severe sleep disorders that present with additional neurological signs and symptoms, even when chronic.Wietse A. WielsYacine BoudibaLaura SeynaeveSylvie De RaedtBrazilian Association of Sleep and Latin American Federation of Sleep Societies articleanti-nmda-receptor encephalitisinsomniaimmune-mediated encephalopathylimbic encephalitisPsychologyBF1-990Consciousness. CognitionBF309-499ENSleep Science, Vol 14, Iss 3, Pp 296-298 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-nmda-receptor encephalitis insomnia immune-mediated encephalopathy limbic encephalitis Psychology BF1-990 Consciousness. Cognition BF309-499
spellingShingle	anti-nmda-receptor encephalitis insomnia immune-mediated encephalopathy limbic encephalitis Psychology BF1-990 Consciousness. Cognition BF309-499 Wietse A. Wiels Yacine Boudiba Laura Seynaeve Sylvie De Raedt Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?
description	We describe an unusual case of severe and chronic insomnia that proved to be eminently treatable. Initially presumed to be of primary psychiatric/toxicological origin, certain clinical and paraclinical clues led us to the diagnosis of NMDA-receptor encephalitis, an immune-mediated disease of the brain. Our patient responded dramatically to immunotherapy, effectively regaining normal sleep habits and significantly improving his general and mental health after 25 years of insomnia and drug abuse. Immune-mediated encephalopathies should be considered in the differential diagnosis of severe sleep disorders that present with additional neurological signs and symptoms, even when chronic.
format	article
author	Wietse A. Wiels Yacine Boudiba Laura Seynaeve Sylvie De Raedt
author_facet	Wietse A. Wiels Yacine Boudiba Laura Seynaeve Sylvie De Raedt
author_sort	Wietse A. Wiels
title	Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?
title_short	Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?
title_full	Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?
title_fullStr	Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?
title_full_unstemmed	Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?
title_sort	anti-nmda-receptor encephalitis: an unusual treatable cause of chronic insomnia?
publisher	Brazilian Association of Sleep and Latin American Federation of Sleep Societies
publishDate	2021
url	https://doaj.org/article/6bb33498eecf4e5687c609fbbe5b8519
work_keys_str_mv	AT wietseawiels antinmdareceptorencephalitisanunusualtreatablecauseofchronicinsomnia AT yacineboudiba antinmdareceptorencephalitisanunusualtreatablecauseofchronicinsomnia AT lauraseynaeve antinmdareceptorencephalitisanunusualtreatablecauseofchronicinsomnia AT sylviederaedt antinmdareceptorencephalitisanunusualtreatablecauseofchronicinsomnia
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Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?

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