Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV

The accumulation of lipid droplets is often observed in hepatitis C virus infection, but the mechanism of their formation is not known. Here the authors show that septin 9 expression is increased in infected livers, and a septin 9/phosphatidylinositol 5-phosphate signalling pathway regulates the gro...

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Autores principales:	Abdellah Akil, Juan Peng, Mohyeddine Omrane, Claire Gondeau, Christophe Desterke, Mickaël Marin, Hélène Tronchère, Cyntia Taveneau, Sokhavuth Sar, Philippe Briolotti, Soumaya Benjelloun, Abdelaziz Benjouad, Patrick Maurel, Valérie Thiers, Stéphane Bressanelli, Didier Samuel, Christian Bréchot, Ama Gassama-Diagne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bbbd7beb26d487f871269821bc6ebff
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spelling	oai:doaj.org-article:6bbbd7beb26d487f871269821bc6ebff2021-12-02T16:49:41ZSeptin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV10.1038/ncomms122032041-1723https://doaj.org/article/6bbbd7beb26d487f871269821bc6ebff2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12203https://doaj.org/toc/2041-1723The accumulation of lipid droplets is often observed in hepatitis C virus infection, but the mechanism of their formation is not known. Here the authors show that septin 9 expression is increased in infected livers, and a septin 9/phosphatidylinositol 5-phosphate signalling pathway regulates the growth of lipid droplets.Abdellah AkilJuan PengMohyeddine OmraneClaire GondeauChristophe DesterkeMickaël MarinHélène TronchèreCyntia TaveneauSokhavuth SarPhilippe BriolottiSoumaya BenjellounAbdelaziz BenjouadPatrick MaurelValérie ThiersStéphane BressanelliDidier SamuelChristian BréchotAma Gassama-DiagneNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abdellah Akil Juan Peng Mohyeddine Omrane Claire Gondeau Christophe Desterke Mickaël Marin Hélène Tronchère Cyntia Taveneau Sokhavuth Sar Philippe Briolotti Soumaya Benjelloun Abdelaziz Benjouad Patrick Maurel Valérie Thiers Stéphane Bressanelli Didier Samuel Christian Bréchot Ama Gassama-Diagne Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV
description	The accumulation of lipid droplets is often observed in hepatitis C virus infection, but the mechanism of their formation is not known. Here the authors show that septin 9 expression is increased in infected livers, and a septin 9/phosphatidylinositol 5-phosphate signalling pathway regulates the growth of lipid droplets.
format	article
author	Abdellah Akil Juan Peng Mohyeddine Omrane Claire Gondeau Christophe Desterke Mickaël Marin Hélène Tronchère Cyntia Taveneau Sokhavuth Sar Philippe Briolotti Soumaya Benjelloun Abdelaziz Benjouad Patrick Maurel Valérie Thiers Stéphane Bressanelli Didier Samuel Christian Bréchot Ama Gassama-Diagne
author_facet	Abdellah Akil Juan Peng Mohyeddine Omrane Claire Gondeau Christophe Desterke Mickaël Marin Hélène Tronchère Cyntia Taveneau Sokhavuth Sar Philippe Briolotti Soumaya Benjelloun Abdelaziz Benjouad Patrick Maurel Valérie Thiers Stéphane Bressanelli Didier Samuel Christian Bréchot Ama Gassama-Diagne
author_sort	Abdellah Akil
title	Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV
title_short	Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV
title_full	Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV
title_fullStr	Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV
title_full_unstemmed	Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV
title_sort	septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by hcv
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6bbbd7beb26d487f871269821bc6ebff
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Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV

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