Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors

The liver parenchyma consists of several cell types, but the origin of this tissue in humans is unclear. Here, the authors perform single cell RNA sequencing of human fetal and adult liver to identify a hepatobiliary hybrid progenitor population of cells, which have a similar gene signature to mouse...

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Autores principales:	Joe M. Segal, Deniz Kent, Daniel J. Wesche, Soon Seng Ng, Maria Serra, Bénédicte Oulès, Gozde Kar, Guy Emerton, Samuel J. I. Blackford, Spyros Darmanis, Rosa Miquel, Tu Vinh Luong, Ryo Yamamoto, Andrew Bonham, Wayel Jassem, Nigel Heaton, Alessandra Vigilante, Aileen King, Rocio Sancho, Sarah Teichmann, Stephen R. Quake, Hiromitsu Nakauchi, S. Tamir Rashid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bbc0c0ed8f149fd9701e5f07676f1d3
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spelling	oai:doaj.org-article:6bbc0c0ed8f149fd9701e5f07676f1d32021-12-02T17:01:31ZSingle cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors10.1038/s41467-019-11266-x2041-1723https://doaj.org/article/6bbc0c0ed8f149fd9701e5f07676f1d32019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11266-xhttps://doaj.org/toc/2041-1723The liver parenchyma consists of several cell types, but the origin of this tissue in humans is unclear. Here, the authors perform single cell RNA sequencing of human fetal and adult liver to identify a hepatobiliary hybrid progenitor population of cells, which have a similar gene signature to mouse oval cells.Joe M. SegalDeniz KentDaniel J. WescheSoon Seng NgMaria SerraBénédicte OulèsGozde KarGuy EmertonSamuel J. I. BlackfordSpyros DarmanisRosa MiquelTu Vinh LuongRyo YamamotoAndrew BonhamWayel JassemNigel HeatonAlessandra VigilanteAileen KingRocio SanchoSarah TeichmannStephen R. QuakeHiromitsu NakauchiS. Tamir RashidNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joe M. Segal Deniz Kent Daniel J. Wesche Soon Seng Ng Maria Serra Bénédicte Oulès Gozde Kar Guy Emerton Samuel J. I. Blackford Spyros Darmanis Rosa Miquel Tu Vinh Luong Ryo Yamamoto Andrew Bonham Wayel Jassem Nigel Heaton Alessandra Vigilante Aileen King Rocio Sancho Sarah Teichmann Stephen R. Quake Hiromitsu Nakauchi S. Tamir Rashid Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
description	The liver parenchyma consists of several cell types, but the origin of this tissue in humans is unclear. Here, the authors perform single cell RNA sequencing of human fetal and adult liver to identify a hepatobiliary hybrid progenitor population of cells, which have a similar gene signature to mouse oval cells.
format	article
author	Joe M. Segal Deniz Kent Daniel J. Wesche Soon Seng Ng Maria Serra Bénédicte Oulès Gozde Kar Guy Emerton Samuel J. I. Blackford Spyros Darmanis Rosa Miquel Tu Vinh Luong Ryo Yamamoto Andrew Bonham Wayel Jassem Nigel Heaton Alessandra Vigilante Aileen King Rocio Sancho Sarah Teichmann Stephen R. Quake Hiromitsu Nakauchi S. Tamir Rashid
author_facet	Joe M. Segal Deniz Kent Daniel J. Wesche Soon Seng Ng Maria Serra Bénédicte Oulès Gozde Kar Guy Emerton Samuel J. I. Blackford Spyros Darmanis Rosa Miquel Tu Vinh Luong Ryo Yamamoto Andrew Bonham Wayel Jassem Nigel Heaton Alessandra Vigilante Aileen King Rocio Sancho Sarah Teichmann Stephen R. Quake Hiromitsu Nakauchi S. Tamir Rashid
author_sort	Joe M. Segal
title	Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
title_short	Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
title_full	Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
title_fullStr	Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
title_full_unstemmed	Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
title_sort	single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6bbc0c0ed8f149fd9701e5f07676f1d3
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Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors

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