Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy

The article presents the results of screening research of influence of sodium alginate with different molecular weight on the development of transplantable tumor in mice and the effectiveness of cytostatic treatment. It was determined that sodium alginates with both high (М = 403 kDa) and low (M = 1...

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Autores principales:	O. Y. Rybalkina, K. A. Lopatina, E. A. Safonova, L. A. Efimova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2014
Materias:	sodium alginate transplantable tumours cyclophosphan Science Q
Acceso en línea:	https://doaj.org/article/6bbd13f36e4747ef9cc69ae0a611624a
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spelling	oai:doaj.org-article:6bbd13f36e4747ef9cc69ae0a611624a2021-11-23T06:14:31ZPerspectives of using sodium alginate with different molecular weight in the complex cancer therapy2541-94202587-9596https://doaj.org/article/6bbd13f36e4747ef9cc69ae0a611624a2014-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1815https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article presents the results of screening research of influence of sodium alginate with different molecular weight on the development of transplantable tumor in mice and the effectiveness of cytostatic treatment. It was determined that sodium alginates with both high (М = 403 kDa) and low (M = 1-10 kDa and M = 1 kDa) molecular weight suppress growth of Ehrlich ascites carcinoma; using sodium alginate (M = 20-30 kDa) in the scheme of chemotherapy increases effectiveness of treatment. Alginates with low molecular weight arrest development of dissemination of Lewis lung carcinoma and sodium alginates (M = 403 kDa and M = 20-30 kDa) in combination with cyclophosphan increase its antimetastatic effect.O. Y. RybalkinaK. A. LopatinaE. A. SafonovaL. A. EfimovaScientific Сentre for Family Health and Human Reproduction Problemsarticlesodium alginatetransplantable tumourscyclophosphanScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5, Pp 63-67 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	sodium alginate transplantable tumours cyclophosphan Science Q
spellingShingle	sodium alginate transplantable tumours cyclophosphan Science Q O. Y. Rybalkina K. A. Lopatina E. A. Safonova L. A. Efimova Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy
description	The article presents the results of screening research of influence of sodium alginate with different molecular weight on the development of transplantable tumor in mice and the effectiveness of cytostatic treatment. It was determined that sodium alginates with both high (М = 403 kDa) and low (M = 1-10 kDa and M = 1 kDa) molecular weight suppress growth of Ehrlich ascites carcinoma; using sodium alginate (M = 20-30 kDa) in the scheme of chemotherapy increases effectiveness of treatment. Alginates with low molecular weight arrest development of dissemination of Lewis lung carcinoma and sodium alginates (M = 403 kDa and M = 20-30 kDa) in combination with cyclophosphan increase its antimetastatic effect.
format	article
author	O. Y. Rybalkina K. A. Lopatina E. A. Safonova L. A. Efimova
author_facet	O. Y. Rybalkina K. A. Lopatina E. A. Safonova L. A. Efimova
author_sort	O. Y. Rybalkina
title	Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy
title_short	Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy
title_full	Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy
title_fullStr	Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy
title_full_unstemmed	Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy
title_sort	perspectives of using sodium alginate with different molecular weight in the complex cancer therapy
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2014
url	https://doaj.org/article/6bbd13f36e4747ef9cc69ae0a611624a
work_keys_str_mv	AT oyrybalkina perspectivesofusingsodiumalginatewithdifferentmolecularweightinthecomplexcancertherapy AT kalopatina perspectivesofusingsodiumalginatewithdifferentmolecularweightinthecomplexcancertherapy AT easafonova perspectivesofusingsodiumalginatewithdifferentmolecularweightinthecomplexcancertherapy AT laefimova perspectivesofusingsodiumalginatewithdifferentmolecularweightinthecomplexcancertherapy
_version_	1718417074284396544

Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy

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