Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia

Human mesenchymal stem cells (hMSC) expressing paracrine factors may enhance therapeutic benefits when transplanted. Here, the authors show that hMSCs stably expressing prostacyclin enhance host regeneration and muscle mass gain in a mouse hindlimb ischaemia model, mediated by the long noncoding RNA...

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Autores principales:	Yuxiao Deng, Zhongwei Yang, Toya Terry, Su Pan, Darren G. Woodside, Jingxiong Wang, Kehe Ruan, James T. Willerson, Richard A. F. Dixon, Qi Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bbe1c11fdeb42e58ccce482da4df04a
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spelling	oai:doaj.org-article:6bbe1c11fdeb42e58ccce482da4df04a2021-12-02T17:32:38ZProstacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia10.1038/ncomms112762041-1723https://doaj.org/article/6bbe1c11fdeb42e58ccce482da4df04a2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11276https://doaj.org/toc/2041-1723Human mesenchymal stem cells (hMSC) expressing paracrine factors may enhance therapeutic benefits when transplanted. Here, the authors show that hMSCs stably expressing prostacyclin enhance host regeneration and muscle mass gain in a mouse hindlimb ischaemia model, mediated by the long noncoding RNA H19.Yuxiao DengZhongwei YangToya TerrySu PanDarren G. WoodsideJingxiong WangKehe RuanJames T. WillersonRichard A. F. DixonQi LiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuxiao Deng Zhongwei Yang Toya Terry Su Pan Darren G. Woodside Jingxiong Wang Kehe Ruan James T. Willerson Richard A. F. Dixon Qi Liu Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
description	Human mesenchymal stem cells (hMSC) expressing paracrine factors may enhance therapeutic benefits when transplanted. Here, the authors show that hMSCs stably expressing prostacyclin enhance host regeneration and muscle mass gain in a mouse hindlimb ischaemia model, mediated by the long noncoding RNA H19.
format	article
author	Yuxiao Deng Zhongwei Yang Toya Terry Su Pan Darren G. Woodside Jingxiong Wang Kehe Ruan James T. Willerson Richard A. F. Dixon Qi Liu
author_facet	Yuxiao Deng Zhongwei Yang Toya Terry Su Pan Darren G. Woodside Jingxiong Wang Kehe Ruan James T. Willerson Richard A. F. Dixon Qi Liu
author_sort	Yuxiao Deng
title	Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
title_short	Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
title_full	Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
title_fullStr	Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
title_full_unstemmed	Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
title_sort	prostacyclin-producing human mesenchymal cells target h19 lncrna to augment endogenous progenitor function in hindlimb ischaemia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6bbe1c11fdeb42e58ccce482da4df04a
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Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia

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