Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia

Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia

Human mesenchymal stem cells (hMSC) expressing paracrine factors may enhance therapeutic benefits when transplanted. Here, the authors show that hMSCs stably expressing prostacyclin enhance host regeneration and muscle mass gain in a mouse hindlimb ischaemia model, mediated by the long noncoding RNA...

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Autores principales: Yuxiao Deng, Zhongwei Yang, Toya Terry, Su Pan, Darren G. Woodside, Jingxiong Wang, Kehe Ruan, James T. Willerson, Richard A. F. Dixon, Qi Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/6bbe1c11fdeb42e58ccce482da4df04a
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