Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation

Abstract As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional r...

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Autores principales:	Kyungsoo Kim, Seung-Jun Yoo, So Yeon Kim, Taeju Lee, Sung-Ho Lim, Jae-Eun Jang, Minkyu Je, Cheil Moon, Ji-Woong Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6bc081db973c4a9cb20ba682f7127ca1
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spelling	oai:doaj.org-article:6bc081db973c4a9cb20ba682f7127ca12021-12-02T18:34:13ZSubthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation10.1038/s41598-021-93354-x2045-2322https://doaj.org/article/6bc081db973c4a9cb20ba682f7127ca12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93354-xhttps://doaj.org/toc/2045-2322Abstract As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery for stroke rehabilitation. In this study, we propose an engineering approach with subthreshold electrical stimulation (STES) to bring functional recovery. Here, we show a low level of electrical stimulation boosted causal excitation in connected neurons and strengthened the synaptic weight in a simulation study. We found that STES with motor training enhanced functional recovery after stroke in vivo. STES was shown to induce neural reconstruction, indicated by higher neurite expression in the stimulated regions and correlated changes in behavioral performance and neural spike firing pattern during the rehabilitation process. This will reduce the energy consumption of implantable devices and the side effects caused by stimulating unwanted brain regions.Kyungsoo KimSeung-Jun YooSo Yeon KimTaeju LeeSung-Ho LimJae-Eun JangMinkyu JeCheil MoonJi-Woong ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyungsoo Kim Seung-Jun Yoo So Yeon Kim Taeju Lee Sung-Ho Lim Jae-Eun Jang Minkyu Je Cheil Moon Ji-Woong Choi Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
description	Abstract As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery for stroke rehabilitation. In this study, we propose an engineering approach with subthreshold electrical stimulation (STES) to bring functional recovery. Here, we show a low level of electrical stimulation boosted causal excitation in connected neurons and strengthened the synaptic weight in a simulation study. We found that STES with motor training enhanced functional recovery after stroke in vivo. STES was shown to induce neural reconstruction, indicated by higher neurite expression in the stimulated regions and correlated changes in behavioral performance and neural spike firing pattern during the rehabilitation process. This will reduce the energy consumption of implantable devices and the side effects caused by stimulating unwanted brain regions.
format	article
author	Kyungsoo Kim Seung-Jun Yoo So Yeon Kim Taeju Lee Sung-Ho Lim Jae-Eun Jang Minkyu Je Cheil Moon Ji-Woong Choi
author_facet	Kyungsoo Kim Seung-Jun Yoo So Yeon Kim Taeju Lee Sung-Ho Lim Jae-Eun Jang Minkyu Je Cheil Moon Ji-Woong Choi
author_sort	Kyungsoo Kim
title	Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_short	Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_full	Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_fullStr	Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_full_unstemmed	Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_sort	subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6bc081db973c4a9cb20ba682f7127ca1
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Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation

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