Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.

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Autores principales:	Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bc41c8173af451ba843ce9103cfc57b
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spelling	oai:doaj.org-article:6bc41c8173af451ba843ce9103cfc57b2021-12-02T18:02:07ZAcetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits10.1038/s41467-021-25280-52041-1723https://doaj.org/article/6bc41c8173af451ba843ce9103cfc57b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25280-5https://doaj.org/toc/2041-1723In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.Jon Palacios-FilardoMatt UdakisGiles A. BrownBenjamin G. TehanMiles S. CongrevePradeep J. NathanAlastair J. H. BrownJack R. MellorNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jon Palacios-Filardo Matt Udakis Giles A. Brown Benjamin G. Tehan Miles S. Congreve Pradeep J. Nathan Alastair J. H. Brown Jack R. Mellor Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
description	In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
format	article
author	Jon Palacios-Filardo Matt Udakis Giles A. Brown Benjamin G. Tehan Miles S. Congreve Pradeep J. Nathan Alastair J. H. Brown Jack R. Mellor
author_facet	Jon Palacios-Filardo Matt Udakis Giles A. Brown Benjamin G. Tehan Miles S. Congreve Pradeep J. Nathan Alastair J. H. Brown Jack R. Mellor
author_sort	Jon Palacios-Filardo
title	Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
title_short	Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
title_full	Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
title_fullStr	Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
title_full_unstemmed	Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
title_sort	acetylcholine prioritises direct synaptic inputs from entorhinal cortex to ca1 by differential modulation of feedforward inhibitory circuits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6bc41c8173af451ba843ce9103cfc57b
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Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

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