Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children

Objectives: Chronic kidney disease (CKD) is a well-established risk factor for cardiovascular diseases. Studies in adults have demonstrated the association between mildly decreased kidney function or even normal values of markers of kidney function to pulse wave velocity (PWV), a measure of arterial...

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Autores principales:	Nataša Marčun Varda, Mirjam Močnik
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	cystatin c creatinine microalbuminuria arterial stiffness pulse wave velocity pulse wave analysis Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/6bc41efb6ecd45a9822931906d52dbca
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spelling	oai:doaj.org-article:6bc41efb6ecd45a9822931906d52dbca2021-11-11T10:40:44ZPulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children1420-40961423-014310.1159/000519340https://doaj.org/article/6bc41efb6ecd45a9822931906d52dbca2021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519340https://doaj.org/toc/1420-4096https://doaj.org/toc/1423-0143Objectives: Chronic kidney disease (CKD) is a well-established risk factor for cardiovascular diseases. Studies in adults have demonstrated the association between mildly decreased kidney function or even normal values of markers of kidney function to pulse wave velocity (PWV), a measure of arterial stiffness and a predictor of cardiovascular events. Our study aimed to evaluate associations between markers of CKD, PWV, and central haemodynamic parameters in children and adolescents at risk of subclinical kidney damage. Methods: 182 children and adolescents with hypertension, obesity, or hypercholesterolaemia (risk factors for subclinical kidney damage) were included in the study. The subjects were subdivided into 4 groups comprising children and adolescents with hypertension (group 1), obesity (group 2), hypercholesterolaemia (group 3), and a group with a combination of risk factors, such as obesity-related hypertension and metabolic syndrome (group 4). The study groups were compared to a group of healthy controls (group 5). PWV was measured by applanation tonometry (SphygmoCor, SCOR-Vx, Sydney, NSW, Australia) and laboratory parameters (serum creatinine, serum cystatin C, and microalbuminuria) were collected. Results: Pearson’s correlation coefficient demonstrated a statistically significant correlation between PWV and serum creatinine in group of all subjects (r = 0.220, p = 0.002). Further subdivision showed the correlation was significant in group 4 (r = 0.370, p = 0.002). In group 2 a correlation between PWV and cystatin C was found (r = −0.535, p = 0.009). In multiple regression analysis of all subjects with PWV as the dependent variable, age and diastolic blood pressure were statistically significant. Correlations between markers of kidney function and central haemodynamic parameters also showed significant correlations between serum creatinine and heart rate (HR) (r = −0.476, p < 0.001) as well as associated parameters (augmentation index, standardized at HR 75/min, ejection duration, and subendocardial viability ratio). Conclusions: Our study demonstrated a correlation between serum creatinine and PWV in children with combined risk factors for atherosclerosis and probable subclinical kidney damage. Further prospective research is needed to confirm the findings, and thus the preventive role of PWV determination in paediatric nephrology.Nataša Marčun VardaMirjam MočnikKarger Publishersarticlecystatin ccreatininemicroalbuminuriaarterial stiffnesspulse wave velocitypulse wave analysisDermatologyRL1-803Diseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the genitourinary system. UrologyRC870-923ENKidney & Blood Pressure Research, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cystatin c creatinine microalbuminuria arterial stiffness pulse wave velocity pulse wave analysis Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923
spellingShingle	cystatin c creatinine microalbuminuria arterial stiffness pulse wave velocity pulse wave analysis Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923 Nataša Marčun Varda Mirjam Močnik Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children
description	Objectives: Chronic kidney disease (CKD) is a well-established risk factor for cardiovascular diseases. Studies in adults have demonstrated the association between mildly decreased kidney function or even normal values of markers of kidney function to pulse wave velocity (PWV), a measure of arterial stiffness and a predictor of cardiovascular events. Our study aimed to evaluate associations between markers of CKD, PWV, and central haemodynamic parameters in children and adolescents at risk of subclinical kidney damage. Methods: 182 children and adolescents with hypertension, obesity, or hypercholesterolaemia (risk factors for subclinical kidney damage) were included in the study. The subjects were subdivided into 4 groups comprising children and adolescents with hypertension (group 1), obesity (group 2), hypercholesterolaemia (group 3), and a group with a combination of risk factors, such as obesity-related hypertension and metabolic syndrome (group 4). The study groups were compared to a group of healthy controls (group 5). PWV was measured by applanation tonometry (SphygmoCor, SCOR-Vx, Sydney, NSW, Australia) and laboratory parameters (serum creatinine, serum cystatin C, and microalbuminuria) were collected. Results: Pearson’s correlation coefficient demonstrated a statistically significant correlation between PWV and serum creatinine in group of all subjects (r = 0.220, p = 0.002). Further subdivision showed the correlation was significant in group 4 (r = 0.370, p = 0.002). In group 2 a correlation between PWV and cystatin C was found (r = −0.535, p = 0.009). In multiple regression analysis of all subjects with PWV as the dependent variable, age and diastolic blood pressure were statistically significant. Correlations between markers of kidney function and central haemodynamic parameters also showed significant correlations between serum creatinine and heart rate (HR) (r = −0.476, p < 0.001) as well as associated parameters (augmentation index, standardized at HR 75/min, ejection duration, and subendocardial viability ratio). Conclusions: Our study demonstrated a correlation between serum creatinine and PWV in children with combined risk factors for atherosclerosis and probable subclinical kidney damage. Further prospective research is needed to confirm the findings, and thus the preventive role of PWV determination in paediatric nephrology.
format	article
author	Nataša Marčun Varda Mirjam Močnik
author_facet	Nataša Marčun Varda Mirjam Močnik
author_sort	Nataša Marčun Varda
title	Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children
title_short	Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children
title_full	Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children
title_fullStr	Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children
title_full_unstemmed	Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children
title_sort	pulse wave velocity, central haemodynamic parameters, and markers of kidney function in children
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/6bc41efb6ecd45a9822931906d52dbca
work_keys_str_mv	AT natasamarcunvarda pulsewavevelocitycentralhaemodynamicparametersandmarkersofkidneyfunctioninchildren AT mirjammocnik pulsewavevelocitycentralhaemodynamicparametersandmarkersofkidneyfunctioninchildren
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Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children

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