Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles

One potential approach for the treatment of Duchenne muscular dysrophy is to increase expression of the dystrophin homolog utrophin. Here, the authors show that eEF1A2 regulates utrophin expression, and show that 2 FDA-approved drugs upregulate eEIF1A2 and utrophin level in mice, leading to improvem...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christine Péladeau, Nadine Adam, Lucas M. Bronicki, Adèle Coriati, Mohamed Thabet, Hasanen Al-Rewashdy, Jason Vanstone, Alan Mears, Jean-Marc Renaud, Martin Holcik, Bernard J. Jasmin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bc7a05ce66e4135bb35be45df6c5df1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6bc7a05ce66e4135bb35be45df6c5df1
record_format	dspace
spelling	oai:doaj.org-article:6bc7a05ce66e4135bb35be45df6c5df12021-12-02T14:40:29ZIdentification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles10.1038/s41467-020-15971-w2041-1723https://doaj.org/article/6bc7a05ce66e4135bb35be45df6c5df12020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15971-whttps://doaj.org/toc/2041-1723One potential approach for the treatment of Duchenne muscular dysrophy is to increase expression of the dystrophin homolog utrophin. Here, the authors show that eEF1A2 regulates utrophin expression, and show that 2 FDA-approved drugs upregulate eEIF1A2 and utrophin level in mice, leading to improvement of the dystrophic phenotype.Christine PéladeauNadine AdamLucas M. BronickiAdèle CoriatiMohamed ThabetHasanen Al-RewashdyJason VanstoneAlan MearsJean-Marc RenaudMartin HolcikBernard J. JasminNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christine Péladeau Nadine Adam Lucas M. Bronicki Adèle Coriati Mohamed Thabet Hasanen Al-Rewashdy Jason Vanstone Alan Mears Jean-Marc Renaud Martin Holcik Bernard J. Jasmin Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles
description	One potential approach for the treatment of Duchenne muscular dysrophy is to increase expression of the dystrophin homolog utrophin. Here, the authors show that eEF1A2 regulates utrophin expression, and show that 2 FDA-approved drugs upregulate eEIF1A2 and utrophin level in mice, leading to improvement of the dystrophic phenotype.
format	article
author	Christine Péladeau Nadine Adam Lucas M. Bronicki Adèle Coriati Mohamed Thabet Hasanen Al-Rewashdy Jason Vanstone Alan Mears Jean-Marc Renaud Martin Holcik Bernard J. Jasmin
author_facet	Christine Péladeau Nadine Adam Lucas M. Bronicki Adèle Coriati Mohamed Thabet Hasanen Al-Rewashdy Jason Vanstone Alan Mears Jean-Marc Renaud Martin Holcik Bernard J. Jasmin
author_sort	Christine Péladeau
title	Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles
title_short	Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles
title_full	Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles
title_fullStr	Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles
title_full_unstemmed	Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles
title_sort	identification of therapeutics that target eef1a2 and upregulate utrophin a translation in dystrophic muscles
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6bc7a05ce66e4135bb35be45df6c5df1
work_keys_str_mv	AT christinepeladeau identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT nadineadam identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT lucasmbronicki identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT adelecoriati identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT mohamedthabet identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT hasanenalrewashdy identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT jasonvanstone identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT alanmears identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT jeanmarcrenaud identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT martinholcik identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles AT bernardjjasmin identificationoftherapeuticsthattargeteef1a2andupregulateutrophinatranslationindystrophicmuscles
_version_	1718390243023912960

Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles

Ejemplares similares