Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.

Human natural killer (NK) cell differentiation, characterized by a loss of NKG2A in parallel with the acquisition of NKG2C, KIRs, and CD57 is stimulated by a number of virus infections, including infection with human cytomegalovirus (CMV), hantavirus, chikungunya virus, and HIV-1. Here, we addressed...

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Autores principales:	Niklas K Björkström, Alexandra Svensson, Karl-Johan Malmberg, Kristina Eriksson, Hans-Gustaf Ljunggren
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6bcb313599a5494c8b90014013de4f74
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spelling	oai:doaj.org-article:6bcb313599a5494c8b90014013de4f742021-11-18T07:34:17ZCharacterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.1932-620310.1371/journal.pone.0027664https://doaj.org/article/6bcb313599a5494c8b90014013de4f742011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22110712/?tool=EBIhttps://doaj.org/toc/1932-6203Human natural killer (NK) cell differentiation, characterized by a loss of NKG2A in parallel with the acquisition of NKG2C, KIRs, and CD57 is stimulated by a number of virus infections, including infection with human cytomegalovirus (CMV), hantavirus, chikungunya virus, and HIV-1. Here, we addressed if HSV-2 infection in a similar way drives NK cell differentiation towards an NKG2A(-)NKG2C(+)KIR(+)CD57(+) phenotype. In contrast to infection with CMV, hantavirus, chikungunya virus, and HIV-1, recurrent HSV-2 infection did not yield an accumulation of highly differentiated NK cells in human peripheral blood. This outcome indicates that human HSV-2 infection has no significant imprinting effect on the human NK cell repertoire.Niklas K BjörkströmAlexandra SvenssonKarl-Johan MalmbergKristina ErikssonHans-Gustaf LjunggrenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27664 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Niklas K Björkström Alexandra Svensson Karl-Johan Malmberg Kristina Eriksson Hans-Gustaf Ljunggren Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.
description	Human natural killer (NK) cell differentiation, characterized by a loss of NKG2A in parallel with the acquisition of NKG2C, KIRs, and CD57 is stimulated by a number of virus infections, including infection with human cytomegalovirus (CMV), hantavirus, chikungunya virus, and HIV-1. Here, we addressed if HSV-2 infection in a similar way drives NK cell differentiation towards an NKG2A(-)NKG2C(+)KIR(+)CD57(+) phenotype. In contrast to infection with CMV, hantavirus, chikungunya virus, and HIV-1, recurrent HSV-2 infection did not yield an accumulation of highly differentiated NK cells in human peripheral blood. This outcome indicates that human HSV-2 infection has no significant imprinting effect on the human NK cell repertoire.
format	article
author	Niklas K Björkström Alexandra Svensson Karl-Johan Malmberg Kristina Eriksson Hans-Gustaf Ljunggren
author_facet	Niklas K Björkström Alexandra Svensson Karl-Johan Malmberg Kristina Eriksson Hans-Gustaf Ljunggren
author_sort	Niklas K Björkström
title	Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.
title_short	Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.
title_full	Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.
title_fullStr	Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.
title_full_unstemmed	Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.
title_sort	characterization of natural killer cell phenotype and function during recurrent human hsv-2 infection.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/6bcb313599a5494c8b90014013de4f74
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Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.

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