Effect of Zinc Oxide (ZnO) Nanoparticles on Death Kinetic of Gram-Negative and Positive Bacterium

BACKGROUND AND OBJECTIVE: Hospital acquired infections are a major problem worldwide and controlling the spread of bacteria within a hospital is a constant challenge so this study was done to survey the effect of ZnO nanoparticles suspension on death kinetic of gram negative and gram bacteria in vit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	E Hoseinzadeh, MR Samarghandi, MY Alikhani, GH Asgari, GH Roshanaei
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	zno kinetic antibacterial activity death rate constant Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6bd111cff1624ee7b164379acbe36957
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6bd111cff1624ee7b164379acbe36957
record_format	dspace
spelling	oai:doaj.org-article:6bd111cff1624ee7b164379acbe369572021-11-10T08:53:26ZEffect of Zinc Oxide (ZnO) Nanoparticles on Death Kinetic of Gram-Negative and Positive Bacterium1561-41072251-7170https://doaj.org/article/6bd111cff1624ee7b164379acbe369572012-09-01T00:00:00Zhttp://jbums.org/article-1-4181-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Hospital acquired infections are a major problem worldwide and controlling the spread of bacteria within a hospital is a constant challenge so this study was done to survey the effect of ZnO nanoparticles suspension on death kinetic of gram negative and gram bacteria in vitro.METHODS: In this experimental study, suspension has been prepared from commercial ZnO nanoparticles in broth medium. After preparing standard strains E. coli ATCC 25922 and P. aeruginosa ATCC 27853 as gram-negative bacteria and S. epidermidis PTCC 1114 and S. aureus ATCC 25923 as gram-positive bacteria, death kinetic study have been evaluated with 1 and 2 times of Minimum Inhibitory Concentration (MIC), and death kinetic study evaluated (at zero to 360 minute of treatment time) using first-order reaction kinetic with 0.5 McFarland standard bacterial suspension (108 cfu/ml).FINDINGS: Effect of ZnO suspension on death kinetic of bacteria showed the survival ratio of bacteria decreased with increasing ZnO concentration. With drawing logarithmic survival ratio and treatment time as ordinate and abscissa, respectively, the population of all strains decreased almost linearly. The apparent death rate constant (k) was found to increase with increasing time and ZnO concentration from 1xMIC to 2xMIC. CONCLUSION: Base on the results, E. coli population at the treatment time decrease faster than others. Also, the results showed that ZnO could be a highly effective disinfect for controlling of gram negative bacteria especially E. coli.E Hoseinzadeh,MR Samarghandi,MY AlikhaniGH AsgariGH RoshanaeiBabol University of Medical Sciencesarticleznokineticantibacterial activitydeath rate constantMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 5, Pp 13-19 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	zno kinetic antibacterial activity death rate constant Medicine R Medicine (General) R5-920
spellingShingle	zno kinetic antibacterial activity death rate constant Medicine R Medicine (General) R5-920 E Hoseinzadeh, MR Samarghandi, MY Alikhani GH Asgari GH Roshanaei Effect of Zinc Oxide (ZnO) Nanoparticles on Death Kinetic of Gram-Negative and Positive Bacterium
description	BACKGROUND AND OBJECTIVE: Hospital acquired infections are a major problem worldwide and controlling the spread of bacteria within a hospital is a constant challenge so this study was done to survey the effect of ZnO nanoparticles suspension on death kinetic of gram negative and gram bacteria in vitro.METHODS: In this experimental study, suspension has been prepared from commercial ZnO nanoparticles in broth medium. After preparing standard strains E. coli ATCC 25922 and P. aeruginosa ATCC 27853 as gram-negative bacteria and S. epidermidis PTCC 1114 and S. aureus ATCC 25923 as gram-positive bacteria, death kinetic study have been evaluated with 1 and 2 times of Minimum Inhibitory Concentration (MIC), and death kinetic study evaluated (at zero to 360 minute of treatment time) using first-order reaction kinetic with 0.5 McFarland standard bacterial suspension (108 cfu/ml).FINDINGS: Effect of ZnO suspension on death kinetic of bacteria showed the survival ratio of bacteria decreased with increasing ZnO concentration. With drawing logarithmic survival ratio and treatment time as ordinate and abscissa, respectively, the population of all strains decreased almost linearly. The apparent death rate constant (k) was found to increase with increasing time and ZnO concentration from 1xMIC to 2xMIC. CONCLUSION: Base on the results, E. coli population at the treatment time decrease faster than others. Also, the results showed that ZnO could be a highly effective disinfect for controlling of gram negative bacteria especially E. coli.
format	article
author	E Hoseinzadeh, MR Samarghandi, MY Alikhani GH Asgari GH Roshanaei
author_facet	E Hoseinzadeh, MR Samarghandi, MY Alikhani GH Asgari GH Roshanaei
author_sort	E Hoseinzadeh,
title	Effect of Zinc Oxide (ZnO) Nanoparticles on Death Kinetic of Gram-Negative and Positive Bacterium
title_short	Effect of Zinc Oxide (ZnO) Nanoparticles on Death Kinetic of Gram-Negative and Positive Bacterium
title_full	Effect of Zinc Oxide (ZnO) Nanoparticles on Death Kinetic of Gram-Negative and Positive Bacterium
title_fullStr	Effect of Zinc Oxide (ZnO) Nanoparticles on Death Kinetic of Gram-Negative and Positive Bacterium
title_full_unstemmed	Effect of Zinc Oxide (ZnO) Nanoparticles on Death Kinetic of Gram-Negative and Positive Bacterium
title_sort	effect of zinc oxide (zno) nanoparticles on death kinetic of gram-negative and positive bacterium
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/6bd111cff1624ee7b164379acbe36957
work_keys_str_mv	AT ehoseinzadeh effectofzincoxideznonanoparticlesondeathkineticofgramnegativeandpositivebacterium AT mrsamarghandi effectofzincoxideznonanoparticlesondeathkineticofgramnegativeandpositivebacterium AT myalikhani effectofzincoxideznonanoparticlesondeathkineticofgramnegativeandpositivebacterium AT ghasgari effectofzincoxideznonanoparticlesondeathkineticofgramnegativeandpositivebacterium AT ghroshanaei effectofzincoxideznonanoparticlesondeathkineticofgramnegativeandpositivebacterium
_version_	1718440382363074560

Effect of Zinc Oxide (ZnO) Nanoparticles on Death Kinetic of Gram-Negative and Positive Bacterium

Ejemplares similares