Respiratory syncytial virus B sequence analysis reveals a novel early genotype

Abstract Respiratory syncytial virus (RSV) is a major cause of respiratory infections and is classified in two main groups, RSV-A and RSV-B, with multiple genotypes within each of them. For RSV-B, more than 30 genotypes have been described, without consensus on their definition. The lack of genotype...

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Autores principales:	Juan C. Muñoz-Escalante, Andreu Comas-García, Sofía Bernal-Silva, Daniel E. Noyola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6bd4dbf975dd46d39d2a4da56eac95b6
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spelling	oai:doaj.org-article:6bd4dbf975dd46d39d2a4da56eac95b62021-12-02T13:30:09ZRespiratory syncytial virus B sequence analysis reveals a novel early genotype10.1038/s41598-021-83079-22045-2322https://doaj.org/article/6bd4dbf975dd46d39d2a4da56eac95b62021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83079-2https://doaj.org/toc/2045-2322Abstract Respiratory syncytial virus (RSV) is a major cause of respiratory infections and is classified in two main groups, RSV-A and RSV-B, with multiple genotypes within each of them. For RSV-B, more than 30 genotypes have been described, without consensus on their definition. The lack of genotype assignation criteria has a direct impact on viral evolution understanding, development of viral detection methods as well as vaccines design. Here we analyzed the totality of complete RSV-B G gene ectodomain sequences published in GenBank until September 2018 (n = 2190) including 478 complete genome sequences using maximum likelihood and Bayesian phylogenetic analyses, as well as intergenotypic and intragenotypic distance matrices, in order to generate a systematic genotype assignation. Individual RSV-B genes were also assessed using maximum likelihood phylogenetic analyses and multiple sequence alignments were used to identify molecular markers associated to specific genotypes. Analyses of the complete G gene ectodomain region, sequences clustering patterns, and the presence of molecular markers of each individual gene indicate that the 37 previously described genotypes can be classified into fifteen distinct genotypes: BA, BA-C, BA-CC, CB1-THB, GB1-GB4, GB6, JAB1-NZB2, SAB1, SAB2, SAB4, URU2 and a novel early circulating genotype characterized in the present study and designated GB0.Juan C. Muñoz-EscalanteAndreu Comas-GarcíaSofía Bernal-SilvaDaniel E. NoyolaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan C. Muñoz-Escalante Andreu Comas-García Sofía Bernal-Silva Daniel E. Noyola Respiratory syncytial virus B sequence analysis reveals a novel early genotype
description	Abstract Respiratory syncytial virus (RSV) is a major cause of respiratory infections and is classified in two main groups, RSV-A and RSV-B, with multiple genotypes within each of them. For RSV-B, more than 30 genotypes have been described, without consensus on their definition. The lack of genotype assignation criteria has a direct impact on viral evolution understanding, development of viral detection methods as well as vaccines design. Here we analyzed the totality of complete RSV-B G gene ectodomain sequences published in GenBank until September 2018 (n = 2190) including 478 complete genome sequences using maximum likelihood and Bayesian phylogenetic analyses, as well as intergenotypic and intragenotypic distance matrices, in order to generate a systematic genotype assignation. Individual RSV-B genes were also assessed using maximum likelihood phylogenetic analyses and multiple sequence alignments were used to identify molecular markers associated to specific genotypes. Analyses of the complete G gene ectodomain region, sequences clustering patterns, and the presence of molecular markers of each individual gene indicate that the 37 previously described genotypes can be classified into fifteen distinct genotypes: BA, BA-C, BA-CC, CB1-THB, GB1-GB4, GB6, JAB1-NZB2, SAB1, SAB2, SAB4, URU2 and a novel early circulating genotype characterized in the present study and designated GB0.
format	article
author	Juan C. Muñoz-Escalante Andreu Comas-García Sofía Bernal-Silva Daniel E. Noyola
author_facet	Juan C. Muñoz-Escalante Andreu Comas-García Sofía Bernal-Silva Daniel E. Noyola
author_sort	Juan C. Muñoz-Escalante
title	Respiratory syncytial virus B sequence analysis reveals a novel early genotype
title_short	Respiratory syncytial virus B sequence analysis reveals a novel early genotype
title_full	Respiratory syncytial virus B sequence analysis reveals a novel early genotype
title_fullStr	Respiratory syncytial virus B sequence analysis reveals a novel early genotype
title_full_unstemmed	Respiratory syncytial virus B sequence analysis reveals a novel early genotype
title_sort	respiratory syncytial virus b sequence analysis reveals a novel early genotype
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6bd4dbf975dd46d39d2a4da56eac95b6
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Respiratory syncytial virus B sequence analysis reveals a novel early genotype

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