The origin and evolution of G protein-coupled receptor kinases.

The origin and evolution of G protein-coupled receptor kinases.

G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling. Direct binding to active GPCRs activates GRKs, so that they selectively pho...

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Autores principales: Arcady Mushegian, Vsevolod V Gurevich, Eugenia V Gurevich
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6bd88114c26a46edb4a39515ee9afd94
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