Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases

Non-coding RNAs (ncRNAs), notably microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), have recently gained increasing consideration because of their versatile role as key regulators of gene expression. They adopt diverse mechanisms to regulate transcription and translation, and thereby, the functi...

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Autores principales:	Dharmendra Kumar Soni, Roopa Biswas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	microRNA long noncoding RNA asthma chronic obstructive pulmonary disease cystic fibrosis idiopathic pulmonary fibrosis Genetics QH426-470
Acceso en línea:	https://doaj.org/article/6bdbc4d7601441389c9cf57aabc748eb
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spelling	oai:doaj.org-article:6bdbc4d7601441389c9cf57aabc748eb2021-11-08T04:42:16ZRole of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases1664-802110.3389/fgene.2021.767348https://doaj.org/article/6bdbc4d7601441389c9cf57aabc748eb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.767348/fullhttps://doaj.org/toc/1664-8021Non-coding RNAs (ncRNAs), notably microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), have recently gained increasing consideration because of their versatile role as key regulators of gene expression. They adopt diverse mechanisms to regulate transcription and translation, and thereby, the function of the protein, which is associated with several major biological processes. For example, proliferation, differentiation, apoptosis, and metabolic pathways demand fine-tuning for the precise development of a specific tissue or organ. The deregulation of ncRNA expression is concomitant with multiple diseases, including lung diseases. This review highlights recent advances in the post-transcriptional regulation of miRNAs and lncRNAs in lung diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis. Further, we also discuss the emerging role of ncRNAs as biomarkers as well as therapeutic targets for lung diseases. However, more investigations are required to explore miRNAs and lncRNAs interaction, and their function in the regulation of mRNA expression. Understanding these mechanisms might lead to early diagnosis and the development of novel therapeutics for lung diseases.Dharmendra Kumar SoniRoopa BiswasFrontiers Media S.A.articlemicroRNAlong noncoding RNAasthmachronic obstructive pulmonary diseasecystic fibrosisidiopathic pulmonary fibrosisGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microRNA long noncoding RNA asthma chronic obstructive pulmonary disease cystic fibrosis idiopathic pulmonary fibrosis Genetics QH426-470
spellingShingle	microRNA long noncoding RNA asthma chronic obstructive pulmonary disease cystic fibrosis idiopathic pulmonary fibrosis Genetics QH426-470 Dharmendra Kumar Soni Roopa Biswas Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases
description	Non-coding RNAs (ncRNAs), notably microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), have recently gained increasing consideration because of their versatile role as key regulators of gene expression. They adopt diverse mechanisms to regulate transcription and translation, and thereby, the function of the protein, which is associated with several major biological processes. For example, proliferation, differentiation, apoptosis, and metabolic pathways demand fine-tuning for the precise development of a specific tissue or organ. The deregulation of ncRNA expression is concomitant with multiple diseases, including lung diseases. This review highlights recent advances in the post-transcriptional regulation of miRNAs and lncRNAs in lung diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis. Further, we also discuss the emerging role of ncRNAs as biomarkers as well as therapeutic targets for lung diseases. However, more investigations are required to explore miRNAs and lncRNAs interaction, and their function in the regulation of mRNA expression. Understanding these mechanisms might lead to early diagnosis and the development of novel therapeutics for lung diseases.
format	article
author	Dharmendra Kumar Soni Roopa Biswas
author_facet	Dharmendra Kumar Soni Roopa Biswas
author_sort	Dharmendra Kumar Soni
title	Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases
title_short	Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases
title_full	Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases
title_fullStr	Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases
title_full_unstemmed	Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases
title_sort	role of non-coding rnas in post-transcriptional regulation of lung diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6bdbc4d7601441389c9cf57aabc748eb
work_keys_str_mv	AT dharmendrakumarsoni roleofnoncodingrnasinposttranscriptionalregulationoflungdiseases AT roopabiswas roleofnoncodingrnasinposttranscriptionalregulationoflungdiseases
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Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases

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